Feed additive composition
Abstract
A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase (e.g. endo-1,4-β-d-xylanase) and a β-glucanase (and optionally a further fibre degrading enzyme), wherein the DFM is selected from the group consisting of an enzyme producing strain; a C5 sugar-fermenting strain; a short-chain fatty acid-producing strain; a fibrolytic, endogenous microflora-promoting strain; or combinations thereof. The DFM may be selected from the group consisting of: Bacillus subtilis AGTP BS3BP5, Bacillus subtilis AGTP BS442, B. subtilis AGTP BS521, B. subtilis AGTP BS918, Bacillus subtilis AGTP BS1013, B. subtilis AGTP BS1069, B. subtilis AGTP 944, B. pumilus AGTP BS 1068 or B. pumilus KX11-1, Enterococcus faecium ID7, Propionibacterium acidipropionici P169, Lactobacillus rhamnosus CNCM-1-3698, Lactobacillus farciminis CNCM-1-3699, a strain having all the characteristics thereof, any derivative or variant thereof, and combinations thereof and the further fibre degrading enzyme may be selected from the group consisting of a cellobiohydrolase (E.C. 3.2.1.176 and E.C. 3.2.1.91), a β-glucosidase (E.C. 3.2.1.21), a β-xylosidase (E.C. 3.2.1.37), a feruloyl esterase (E.C. 3.1.1.73), an α-arabinofuranosidase (E.C. 3.2.1.55), a pectinase (e.g. an endopolygalacturonase (E.C. 3.2.1.15), an exopolygalacturonase (E.C. 3.2.1.67) or a pectate lyase (E.C. 4.2.2.2)), or combinations thereof.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase and a β-glucanase, wherein the DFM is selected from the group consisting of an enzyme producing strain; a C5 sugar-fermenting strain; a short-chain fatty acid-producing strain; a fibrolytic, endogenous microflora-promoting strain; or combinations thereof.
2 . A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving feed conversion ratio (FCR), or for improving weight gain in a subject, or for improving feed efficiency in a subject, or for shifting the fermentation process in the subject's gastrointestinal tract towards the production of butyric acid and/or propionic acid, which method comprising administering to a subject the feed additive composition of claim 1 .
3 - 6 . (canceled)
7 . The feed additive composition of claim 1 , wherein the DFM comprises at least one strain of bacterium selected from the group consisting of the following genera: Bacillus, Enterococcus, Lactobacillus, Propionibacterium and combinations thereof.
8 . The feed additive composition of claim 7 , wherein the DFM comprises at least one strain selected from the Bacillus genus, particularly Bacillus subtilis, B. licheniformis, B. amyloliquefaciens or B. pumilus.
9 . The feed additive composition of claim 7 , wherein the DFM is selected from the group consisting of: Bacillus subtilis AGTP BS3BP5, Bacillus subtilis AGTP BS442, B. subtilis AGTP BS521, B. subtilis AGTP BS918, Bacillus subtilis AGTP BS1013, B. subtilis AGTP BS1069, B. subtilis AGTP 944, B. pumilus AGTP BS 1068 or B. pumilus KX11-1, Enterococcus faecium ID7, Propionibacterium acidipropionici P169, Lactobacillus rhamnosus CNCM-I-3698, Lactobacillus farciminis CNCM-I-3699, a strain having all the characteristics thereof, any derivative or variant thereof, and combinations thereof.
10 . The feed additive composition of claim 1 , wherein the DFM is a viable bacterium.
11 . The feed additive composition of claim 1 , wherein the direct fed microbial is in the form of an endospore.
12 . The feed additive composition of claim 1 wherein the xylanase is an endo-1,4-β-d-xylanase.
13 . The feed additive composition of claim 1 , wherein the feed additive composition comprises a further fibre degrading enzyme.
14 . The method of claim 2 , wherein the method further comprises administering to a subject a further fibre degrading enzyme.
15 . The feed additive composition of claim 13 , wherein the further fibre degrading enzyme is selected from the group consisting of a cellobiohydrolase (E.C. 3.2.1.176 and E.C. 3.2.1.91), a β-glucosidase (E.C. 3.2.1.21), a β-xylosidase (E.C. 3.2.1.37), a feruloyl esterase (E.C. 3.1.1.73), an α-arabinofuranosidase (E.C. 3.2.1.55), a pectinase (e.g. an endopolygalacturonase (E.C. 3.2.1.15), an exopolygalacturonase (E.C. 3.2.1.67) or a pectate lyase (E.C. 4.2.2.2)), or combinations thereof.
16 . The feed additive composition of claim 15 , wherein the further fibre degrading enzyme is selected from the group consisting of a cellobiohydrolase (E.C. 3.2.1.176 and E.C. 3.2.1.91), a β-glucosidase (E.C. 3.2.1.21) or combinations thereof.
17 . A premix comprising the feed additive composition of claim 1 , (and optionally a further fibre degrading enzyme), and at least one vitamin and/or at least one mineral.
18 . A feed comprising the feed additive composition of claim 1 .
19 . A method of preparing a feedstuff comprising admixing a feed component with the feed additive composition of claim 1 .
20 . A method of preparing a feedstuff comprising admixing a feed component with the premix of claim 17 .
21 . (canceled)
22 . (canceled)
23 . A kit comprising a direct fed microbial (DFM), a xylanase and a β-glucanase (and optionally a further fibre degrading enzyme), wherein the DFM is selected from the group consisting of an enzyme producing strain; a C5 sugar-fermenting strain; a short-chain fatty acid-producing strain; a fibrolytic, endogenous microflora-promoting strain; or combinations thereof (and optionally at least one vitamin and/or optionally at least one mineral) and instructions for administration.
24 . (canceled)
25 . (canceled)
26 . A feed comprising the premix of claim 17 .Join the waitlist — get patent alerts
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