Composition comprising an organic liquid diluent and a cellulose ether of very low viscosity

Abstract

A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.

1 . A liquid composition comprising an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity from 1.20 to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C. according to Ubbelohde. 
     
     
         2 . The liquid composition of  claim 1  additionally comprising at least one active ingredient and optionally one or more adjuvants. 
     
     
         3 . The liquid composition of  claim 1  wherein the cellulose ether has a viscosity of from 1.20 to 2.26 mPa·s, measured as a 2 wt.-% solution in water at 20° C. 
     
     
         4 . The liquid composition of  claim 1  wherein said at least one cellulose ether is a hydroxyalkyl alkylcellulose or an alkylcellulose. 
     
     
         5 . The liquid composition of  claim 1  wherein said at least one cellulose ether has a degree of alkyl substitution, DS(alkyl), of from 1.0 to 2.5. 
     
     
         6 . The liquid composition of  claim 1  wherein said at least one cellulose ether has a molar substitution of hydroxyalkoxyl groups, MS (hydroxyalkyl) of 0 to 1.10. 
     
     
         7 . The liquid composition of  claim 1  wherein the composition additionally comprises water and the composition comprises more than 50 weight percent of an organic liquid diluent and less than 50 weight percent of water, based on the total weight of organic liquid diluent and water. 
     
     
         8 . (canceled) 
     
     
         9 . A solid dispersion comprising at least one active ingredient in at least one cellulose ether having a viscosity from 1.20 to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C. according to Ubbelohde. 
     
     
         10 . The solid dispersion of  claim 9  wherein the solid dispersion has been formulated into pellets, granules, pills, tablets, caplets, capsules microparticles, fillings of capsules or into a powder, paste, cream, suspension or slurry. 
     
     
         11 . A process for producing the solid dispersion of  claim 9  comprising the steps of blending a) at least one cellulose ether having a viscosity from 1.20 to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C. according to Ubbelohde, b) one or more active ingredients and c) one or more optional additives, and subjecting the blend to extrusion. 
     
     
         12 . A process for producing the solid dispersion of  claim 9  comprising the steps of providing the liquid composition of  claim 2  and removing liquid diluent from the liquid composition. 
     
     
         13 . The process of  claim 12  wherein liquid diluent is removed from the liquid composition by spray-drying, by casting the liquid composition into a film or a capsule or by applying the liquid composition onto a solid carrier. 
     
     
         14 . A process for coating a dosage form comprising the step of contacting the liquid composition of  claim 1  with the dosage form. 
     
     
         15 . A process for the manufacture of capsules comprising the step of contacting the liquid composition of  claim 1  with dipping pins.