Carrier pellets, method for production thereof and use thereof

Abstract

The invention relates to a method for the production of carrier pellets for pharmaceutical active substances. Likewise, the invention relates to such carrier pellets and also to pharmaceutical formulations containing these. The carrier pellets according to the invention are used for transporting and releasing pharmaceutical active substances, in particular in the human body.

1 . A carrier pellet for carrying a pharmaceutically active substance, the carrier pellet comprising at least one physiologically well-tolerated pH regulator, wherein the carrier pellets are produced by the method comprising:
 a) producing a liquid formulation by dissolving, dispersing, or a combination of dissolving and dispersing at least one physiologically well-tolerated pH regulator in at least one solvent or emulsifier;   b) introducing the liquid formulation into a fluidized-bed or spouted-bed unit using at least one nozzle;   c) forming essentially spherical carrier pellets by spray granulation in the unit wherein the solvent is evaporated by a drying gas flow; and   d) discharging the carrier pellets from the unit.   
     
     
         2 . The carrier pellet according to  claim 1 ;
 wherein the carrier pellet has a diameter in the range of 50 μm to 1.5 mm.   
     
     
         3 . The carrier pellet according to  claim 1 ;
 wherein the carrier pellet is essentially spherical.   
     
     
         4 . The carrier pellet according to  claim 3 ;
 wherein the carrier pellet has a sphericity of 0.8 to 1.0.   
     
     
         5 . The carrier pellet according to  claim 1 ;
 wherein the carrier pellet has a width-length ratio of 0.8 to 1.0.   
     
     
         6 . The carrier pellet according to  claim 1 ;
 wherein the carrier pellet is a dense carrier pellet.   
     
     
         7 . A combination of carrier pellets comprising:
 at two of the carrier pellets according  claim 1 ;   wherein at least two of the carrier pellets in the combination have essentially the same size.   
     
     
         8 . A pharmaceutical formulation comprising:
 one or more carrier pellets according to  claim 1 ; and   at least one pharmaceutically active substance.   
     
     
         9 . A method of releasing a pharmaceutically active substance, the method comprising:
 introducing one or more pharmaceutical formulations according to  claim 8  into physiological surroundings, wherein the one or more carrier pellets releases the pharmaceutically active substance into the physiological surroundings.