Methods of electrospray chemical synthesis

Abstract

The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization for use in chemical synthesis and expedited organic chemical reactions.

I/We claim: 
     
         1 . A method of preparing and recovering a reaction product, comprising causing a chemical reaction by passing a reactant through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture, wherein said chemical reaction comprises a formation of a covalent bond. 
     
     
         2 . A method as claimed in  claim 1 , wherein said reaction product is in a quantity greater than 1 milligram. 
     
     
         3 . A method of as claimed in  claim 1 , wherein said covalent bond comprises a carbon-carbon, carbon-oxygen, carbon-hydrogen, oxygen-hydrogen, carbon-phosphorous, phosphorous-oxygen, phosphorous-nitrogen, carbon-sulfur, carbon-halogen, carbon-nitrogen, carbon-boron, sulfur-nitrogen, carbon-silicon, oxygen-silicon, oxygen-oxygen, oxygen-nitrogen, nitrogen-nitrogen, sulfur-sulfur, or carbon-selenium bond. 
     
     
         4 . A method as claimed in  claim 1 , wherein said reaction product is an oxidation reaction product, and said chemical reaction comprises passing a reactant through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         5 . A method as claimed in  claim 1 , wherein said reaction product is a reduction reaction product, and said chemical reaction comprises passing a reactant through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         6 . A method as claimed in  claim 1 , wherein said reaction product is an aldol condensation reaction product, and said chemical reaction comprises passing an enol compound and a carbonyl compound through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         7 . A method as claimed in  claim 1 , wherein said reaction product is an amide, and said chemical reaction comprises passing a carboxylic acid and an amine through an electrospray to provide a reaction mixture and recovering said amide from the reaction mixture. 
     
     
         8 . A method as claimed in  claim 1 , wherein said reaction product is a secondary amine, and said chemical reaction comprises passing a nitro compound through an electrospray to provide a reaction mixture and recovering said secondary amine from the reaction mixture. 
     
     
         9 . A method as claimed in  claim 1 , wherein said reaction product is an imine, and said chemical reaction comprises passing an amine and an aldehyde through an electrospray to provide a reaction mixture and recovering said imine from the reaction mixture. 
     
     
         10 . A method as claimed in  claim 1 , wherein said reaction product is an alkyl amine, and said chemical reaction comprises passing an amine and an alkyl halide through an electrospray to provide a reaction mixture and recovering said alkyl amine from the reaction mixture. 
     
     
         11 . A method as claimed in  claim 1 , wherein said reaction product results from the hydrolysis of an ester, and said chemical reaction comprises passing an ester through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         12 . A method as claimed in  claim 1 , wherein said reaction product is a mono or di acetyl, and said chemical reaction comprises passing an alcohol and an aldehyde through an electrospray to provide a reaction mixture and recovering said mono or di acetyl from the reaction mixture. 
     
     
         13 . A method as claimed in  claim 1 , wherein said reaction product is an alcohol and carboxylic acid, and said chemical reaction comprises passing an ester through an electrospray to provide a reaction mixture and recovering said alcohol and carboxylic acid from the reaction mixture. 
     
     
         14 . A method as claimed in  claim 1 , wherein said reaction product is an alcohol oxidation product, and said chemical reaction comprises passing an alcohol through an electrospray to provide a reaction mixture and recovering said alcohol oxidation product from the reaction mixture. 
     
     
         15 . A method as claimed in  claim 1 , wherein said reaction product results from the alkyation of an amine, and said chemical reaction comprises passing an amine and alkyl halide through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         16 . A method as claimed in  claim 1 , wherein said chemical reaction comprises preparing and recovering a Suzuki reaction product, by passing aryl- or vinyl-boronic acid with an aryl- or vinyl-halide through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         17 . A method as claimed in  claim 1 , wherein said chemical reaction comprises preparing a Heck reaction product, by passing aryl- or vinyl-halide with an alkene, through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         18 . A method as claimed in  claim 1 , wherein said reaction product comprises an ester, and said chemical reaction comprises passing an acid and an alcohol through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         19 . A method as claimed in  claim 1 , wherein said chemical product comprises a cyclized molecule and said chemical reaction comprises passing a cyclizable molecule through an electrospray to provide a reaction mixture and recovering said reaction product from the reaction mixture. 
     
     
         20 . The method of  claim 1  wherein the capillary voltage of the electrospray is between 1.0 to 4.0 kV. 
     
     
         21 . The method according to  claim 1 , wherein the reaction product is enriched by passing the reaction mixture through a second electrospray.