Advanced glycation end product analogues

Abstract

Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

1 . A process for the production of composition comprising one or more fructose amino acids, said process comprising the steps of:
 (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae;   (b) extracting one or more fructose amino acid(s) from said plant material; and optionally   (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).   
     
     
         2 . The process of  claim 1  wherein the botanical source comprises plants of the species  Hypericum perforatum.    
     
     
         3 . The process of  claim 1  for the production of a pharmaceutical composition, further comprising the step of formulating said extracted fructose amino acid(s) with a pharmaceutically-acceptable excipient or carrier. 
     
     
         4 . The process of  claim 1  for the production of a cosmetic composition, further comprising the step of formulating said extracted fructose amino acid(s) with a cosmetically-acceptable excipient or carrier. 
     
     
         5 . The process of  claim 1  for the production of a nutraceutical composition, further comprising the step of formulating said extracted fructose amino acid(s) with a nutraceutically-acceptable excipient or carrier. 
     
     
         6 . The process of  claim 1  wherein the amount and concentration of the extracted fructose amino acids is: (a) sufficient to treat AGE-mediated disease in a subject; (b) sufficient to produce an anti-diabetic effect in a subject; (c) sufficient to produce an anti-depressant effect in a subject; and/or (d) sufficient to produce an anti-inflammatory effect in a subject. 
     
     
         7 . The process of  claim 1  further comprising isolating, and optionally purifying, the extracted fructose amino acid(s). 
     
     
         8 . The process of  claim 1  wherein the extracted, isolated or purified fructose amino acid(s) is(are) present in the composition at a level of at least: 5% w/w, 10% w/w; 15% w/w; 20% w/w; 25% w/w; 30% w/w; 35% w/w; 40% w/w; 45% w/w; 50% w/w, 60% w/w, 70% w/w, 80% w/w, 90% w/w, 99% w/w (on a dry weight basis). 
     
     
         9 . The process of  claim 1  wherein the botanical source comprises plants of the genera  Hypericum, Lycium, Cissus, Matricaria, Stevia, Angelica, Sanguinaria, Andrographis, Solanum  or  Conopodium.    
     
     
         10 . The process of  claim 9  wherein the botanical source comprises: (a) Solanaceae fruit, for example Goji berries ( Lycium ), or tubers, for example potatoes; and/or (b) fruits, flowers, roots or leaves from plants of  Stevia rebaudiana ; and/or (c) fruits, flowers, roots or leaves from plants of  Matricaria chamomilla.    
     
     
         11 . A composition obtainable by the process of  claim 1 . 
     
     
         12 . A process for producing a cosmetic, nutraceutical or pharmaceutical composition, or herbal medicine, comprising the step of monitoring the quality of said cosmetic, nutraceutical or pharmaceutical composition, or herbal medicine, by detecting the presence or absence or measuring the amount of a fructose amino acid in a sample of said cosmetic, nutraceutical or pharmaceutical composition, or herbal medicine, wherein the cosmetic, nutraceutical or pharmaceutical composition, herbal medicine or sample is derived from a botanical source selected from plants of the families Solanaceae, Compositae (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae. 
     
     
         13 . A process for producing a cosmetic, nutraceutical or pharmaceutical composition, or herbal medicine, comprising the step of monitoring the quality of said cosmetic, nutraceutical or pharmaceutical composition, or herbal medicine, by detecting the presence or absence or measuring the amount of a fructose amino acid in a sample of said cosmetic, nutraceutical or pharmaceutical composition, or herbal medicine, wherein the cosmetic, nutraceutical or pharmaceutical composition, herbal medicine or sample is derived from a botanical source selected from plants of the families Solanaceae, Compositae (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae wherein the botanical source is as defined in  claim 1 . 
     
     
         14 . A composition comprising an isolated fructose amino acid for use in therapy or prophylaxis, wherein the fructose amino acid is selected from:
 (a) N2-fructopyranosylhomoarginine;   (b) Fructose homoarginine;   (c) N2-(β-D-Fructopyranos-1-yl-Arginine;   (d) fructose lysine;   (e) fructose serine;   (f) 1-Deoxy-1-(N-γ-aminobutyric acid)fructose; and   (g) pharmaceutically acceptable salts, solvates, metabolites, prodrugs, bioisosteres, derivatives and protected forms of any one of (a)-(g).   
     
     
         15 . The composition of  claim 14  wherein the isolated fructose amino acid is present in the composition at a level of at least: 5% w/w, 10% w/w; 15% w/w; 20% w/w; 25% w/w; 30% w/w; 35% w/w; 40% w/w; 45% w/w; 50% w/w, 60% w/w, 70% w/w, 80% w/w, 90% w/w, 99% w/w (on a dry weight basis).