US2015190514A1PendingUtilityA1

Stabilizing polypeptides which have been exposed to urea

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Assignee: GENENTECH INCPriority: Dec 19, 2001Filed: Mar 18, 2015Published: Jul 9, 2015
Est. expiryDec 19, 2021(expired)· nominal 20-yr term from priority
Inventors:Jefferson C. EmeryPaul J. McdonaldRhona O'Leary
A61P 43/00C07K 16/32A61K 39/39591A61K 47/183C07K 16/2863C07K 2317/76C07K 2317/24A61K 47/18A61K 39/3955C07K 16/065
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Claims

Abstract

Methods for stabilizing polypeptides, such as anti-HER2 antibodies, which have been exposed to urea.

Claims

exact text as granted — not AI-modified
What is claimed: 
     
         1 . An isolated composition comprising a purified anti-HER2 antibody, and urea and an amino acid added to said antibody. 
     
     
         2 . The composition of  claim 1  wherein the anti-HER2 antibody is monoclonal. 
     
     
         3 . The composition of  claim 2  wherein the anti-HER2 antibody is an antibody fragment. 
     
     
         4 . The composition of  claim 2  wherein purification of the anti-HER2 antibody includes Protein A chromatography. 
     
     
         5 . The composition of  claim 2  which is an aqueous solution. 
     
     
         6 . The composition of  claim 5  which consists essentially of a purified anti-HER2 antibody, urea, an amino acid and water.

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