US2015175545A1PendingUtilityA1

Preparation Method of Fluoro-Substituted Deuterated Diphenylurea

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Assignee: SUZHOU ZELGEN BIOPHARMACEUTICAL CO LTDPriority: Sep 18, 2012Filed: Mar 4, 2015Published: Jun 25, 2015
Est. expirySep 18, 2032(~6.1 yrs left)· nominal 20-yr term from priority
Inventors:Weidong FengXiaoyong GaoXiaojun Dai
C07C 309/30C07D 213/81C07C 31/08C07C 309/04
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Claims

Abstract

A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A salt or solvate of following formula, 
       
         
           
           
               
               
           
         
         comprising a p-toluenesulfonate of following formula, 
       
       
         
           
           
               
               
           
         
         which is 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl]ureido)-3-fluorophenoxy)-N-(methyl-d 3 ) picolinamide p-toluenesulfonate (CM4309.TsOH), 
         a hydrochloride of following formula, 
       
       
         
           
           
               
               
           
         
         which is 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl]ureido)-3-fluorophenoxy)-N-(methyl-d 3 ) picolinamide hydrochloride (CM4309.HCl), or 
         a methanesulfonic acid ethanol complex of following formula, 
       
       
         
           
           
               
               
           
         
         which is 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl]ureido)-3-fluorophenoxy)-N-(methyl-d 3 ) picolinamide methanesulfonic acid ethanol complex (1:1:1) (CM4309.MeSO 3 H.CH 3 CH 2 OH).

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