US2015150865A1PendingUtilityA1

Combination drug for treating vascular disorder

Assignee: OTSUKA PHARMA CO LTDPriority: Mar 14, 2008Filed: Feb 6, 2015Published: Jun 4, 2015
Est. expiryMar 14, 2028(~1.6 yrs left)· nominal 20-yr term from priority
A61P 9/10A61P 43/00A61P 9/00A61P 25/00A61K 31/4709A61K 31/205A61K 31/4704
34
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Claims

Abstract

The present invention relates to a medicament for treating occlusive and/or ischemic vascular disorder comprising a carbostyril derivative and carnitine.

Claims

exact text as granted — not AI-modified
1 - 17 . (canceled) 
     
     
         18 . A method for treating cerebrovascular accident comprising administering to a patient in need thereof a therapeutically effective amount of a combination comprising as active ingredients
 6-[4-(1-cyclohexyl-1H-1-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof, and carnitine or a salt thereof, in a ratio of 0.1 to 100 parts by weight of carnitine or a salt thereof per 1 part by weight of the carbostyril derivative or a salt thereof.   
     
     
         19 . The method of  claim 18  wherein the cerebrovascular accident is acute cerebral infarction, chronic cerebral infarction, transient ischemic attack, intracerebral hemorrhage, subarachnoid hemorrhage, subdural hematoma, cerebrocortical dysfunction, or cranial neuronal cell death. 
     
     
         20 . The method of  claim 18  wherein the carnitine is L-carnitine or levocarnitine chloride. 
     
     
         21 . The method of  claim 18  wherein the ratio is 1 to 20 parts by weight of carnitine or a salt thereof per 1 part by weight of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof.

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