Composition and method for compounded therapy

Abstract

The present embodiments relate to topically delivered compounded medications. A transdermal cream may provide the effective topical administration of multiple medications simultaneously. The transdermal cream may include low concentrations of local anesthetics, a NSAID, an anticonvulsant, and/or other active ingredients. The transdermal cream may include lidocaine, prilocaine, meloxicam, and lamotrigine and/or topiramate. Alternatively, the transdermal cream may include a lidocaine/prilocaine base cream to which is added a fine powder of one or more ground up medications to form a compounded medication. The compounded medication in powder form may be generated from grinding up tablets of NSAIDs, anticonvulsants, nerve depressants, antidepressants, muscle relaxants, NMDA receptor antagonists, opiate or opioid agonists, and/or other agents. The compounded medication in powder form may include meloxicam, lamotrigine, topiramate, other active ingredients, and DMSO or Sterile Water for Irrigation. In another aspect, the present embodiments relate to methods of compounding medications and transdermal creams or gels.

1 . A method of compounding medication with a transdermal cream for the topical administration of a compounded therapy, the method comprising:
 grinding up one or more commercial tablets selected from a NSAID (Non-Steroidal Anti-Inflammatory Drug), an anticonvulsant, a nerve depressant, a muscle relaxant, a NMDA (N-Methyl-D-aspartate) receptor antagonist, an opiate or opioid agonist, and an antidepressant into a fine powder of medication; and   adding the fine powder of medication to a transdermal cream containing lidocaine in an amount between approximately 0.5% and approximately 5.0% by weight of the transdermal cream and prilocaine in an amount between approximately 0.5% and 5.0% by weight of the transdermal cream.   
     
     
         2 . The method of  claim 1 , wherein the grinding comprises grinding up one or more commercial tablets of the NSAID into the fine powder of medication such that the transdermal cream includes an amount of the NSAID of between approximately 0.05% and approximately 0.15% by weight of the transdermal cream, the NSAID being meloxicam. 
     
     
         3 . The method of  claim 1 , wherein the grinding further comprises grinding up one or more commercial tablets of the anticonvulsant into the fine powder of medication such that the transdermal cream includes an amount of the anticonvulsant of between approximately 2.0% and approximately 3.0% by weight of the transdermal cream, the anticonvulsant being lamotrigine or topiramate. 
     
     
         4 . The method of  claim 1 , wherein the grinding comprises grinding up one or more commercial tablets of the NSAID into the fine powder of medication, the NSAID being meloxicam, and one or more commercial tablets of the anticonvulsant into the fine powder of medication, the anticonvulsant being one of topiramate and lamotrigine, wherein after the fine powder of medication is added to the transdermal cream, the transdermal cream includes meloxicam in an amount of between approximately 0.05% and approximately 0.15% by weight of the transdermal cream and the one of topiramate and lamotrigine in an amount of between approximately 2.0% and approximately 3.0% by weight of the transdermal cream. 
     
     
         5 . (canceled) 
     
     
         6 . The method of  claim 1 , further comprising wetting the fine powder of medication with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding the fine powder of medication to the transdermal cream. 
     
     
         7 . The method of  claim 6 , wherein the grinding comprises grinding up one or more commercial tablets of the NSAID into the fine powder of medication such that the transdermal cream includes an amount of the NSAID of between approximately 0.05% and approximately 0.15% by weight of the transdermal cream, the NSAID being meloxicam. 
     
     
         8 . The method of  claim 6 , wherein the grinding further comprises grinding up one or more commercial tablets of the anticonvulsant into the fine powder of medication such that the transdermal cream includes an amount of the anticonvulsant of between approximately 2.0% and approximately 3.0% by weight of the transdermal cream, the anticonvulsant being lamotrigine or topiramate. 
     
     
         9 - 10 . (canceled) 
     
     
         11 . A method of compounding medications with a transdermal cream for the topical administration of a compounded therapy, the method comprising:
 grinding up one or more commercial tablets of each of two or more medications into a fine powder of medication, the two or more medications comprising meloxicam and at least one of topiramate and lamotrigine; and   adding the fine powder of medication to a transdermal cream containing lidocaine in an amount between approximately 0.5% and approximately 5.0% by weight of the transdermal cream and prilocaine in an amount between approximately 0.5% and 5.0% by weight of the transdermal cream.   
     
     
         12 - 13 . (canceled) 
     
     
         14 . The method of  claim 11 , wherein after the fine powder of medication is added to the transdermal cream, the transdermal cream includes meloxicam in an amount of between approximately 0.05% and approximately 0.15% by weight of the transdermal cream and at least one of topiramate and lamotrigine in an amount of between approximately 2.0% and approximately 3.0% by weight of the transdermal cream. 
     
     
         15 . The method of  claim 11 , further comprising wetting the fine powder of medication with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation. 
     
     
         16 - 17 . (canceled) 
     
     
         18 . The method of  claim 15 , wherein after the fine powder of medication is added to the transdermal cream, the transdermal cream includes meloxicam in an amount of between approximately 0.05% and approximately 0.15% by weight of the transdermal cream and at least one of topiramate and lamotrigine in an amount of between approximately 2.0% and approximately 3.0% by weight of the transdermal cream. 
     
     
         19 . A method of making a compounded transdermal cream, the method comprising:
 adding one or more fine powders of medication to a volume of lidocaine and prilocaine cream 2.5%/2.5%, wherein the medication is selected from
 a NSAID (Non-Steroidal Anti-Inflammatory Drug), 
 an anticonvulsant, 
 a nerve depressant, 
 a muscle relaxant, 
 a NMDA (N-Methyl-D-aspartate) receptor antagonist, 
 an opiate or opioid agonist, and 
 an antidepressant. 
   
     
     
         20 . The method of  claim 19 , further comprising wetting at least one of the one or more fine powders of medication with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         21 . The method of  claim 19 , wherein the selected medication comprises meloxicam in an amount between approximately 0.05% and approximately 0.15% by weight of the compounded transdermal cream. 
     
     
         22 . The method of  claim 21 , further comprising wetting the fine powder of meloxicam with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         23 . The method of  claim 19 , wherein the selected medication comprises one of lamotrigine and topiramate in an amount between approximately 2.0% and approximately 3.0% by weight of the compounded transdermal cream. 
     
     
         24 . The method of  claim 23 , further comprising wetting the fine powder of the one of lamotrigine and topiramate with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         25 . The method of  claim 19 , wherein the selected medication comprises meloxicam in an amount between approximately 0.05% and approximately 0.15% by weight of the compounded transdermal cream and one of lamotrigine and topiramate in an amount of between approximately 2.0% and approximately 3.0% by weight of the compounded transdermal cream. 
     
     
         26 . The method of  claim 25 , further comprising wetting the fine powders of meloxicam and the one of lamotrigine, and topiramte with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         27 . The method of  claim 19 , further comprising grinding up one or more commercial tablets of at least one selected medication into a fine powder to form the fine powder of the selected medication. 
     
     
         28 . The method of  claim 27 , further comprising wetting at least one of the one or more fine powders of medication with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         29 . The method of  claim 27 , wherein the selected medication comprises meloxicam in an amount between approximately 0.05% and approximately 0.15% by weight of the compounded transdermal cream, and wherein the method further comprises grinding up one or more commercial tablets of meloxicam to form the fine powder of meloxicam. 
     
     
         30 . The method of  claim 28 , further comprising wetting the fine powder of meloxicam with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         31 . The method of  claim 27 , wherein the selected medication comprises one of lamotrigine and topiramate in an amount between approximately 2.0% and approximately 3.0% by weight of the compounded transdermal cream, and wherein the method further comprises grinding up one or more commercial tablets of the one of lamotrigine and topiramate to form the fine powder of the one of lamotrigine and topiramate. 
     
     
         32 . The method of  claim 31 , further comprising wetting the fine powder of the one of lamotrigine and topiramate with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%. 
     
     
         33 . The method of  claim 27 , wherein the selected medication comprises meloxicam in an amount between approximately 0.05% and approximately 0.15% by weight of the compounded transdermal cream and one of lamotrigine and topiramate in an amount of between approximately 2.0% and approximately 3.0% by weight of the compounded transdermal cream, and wherein the method further comprises grinding up one or more commercial tablets of the meloxicam and the one of lamotrigine and topiramate to form the fine powders of meloxicam and the one of lamotrigine and topiramate. 
     
     
         34 . The method of  claim 33 , further comprising wetting the fine powders of meloxicam and the one of lamotrigine, and topiramate with dimethyl sulfoxide (DMSO) or Sterile Water for Irrigation before adding to the lidocaine and prilocaine cream 2.5%/2.5%.