Octenidine composition

Abstract

The invention relates to octenidine or a pharmaceutical salt thereof, in particular octenidine dihydrochloride, which is intended for mutual therapeutic administration of the octenidine in solution with a polyalcohol of formula (1a) or (1b): (H—C—OH) a (HO—C—OH) b (H—C—H) c (CHO)  (1a), (H—C—OH) a (HO—C—OH) b (H—C—H) c (CO)  (1b), wherein a, b, c are whole numbers, where a+b is at least 2, preferably at least 3, c is selected from 0, 1 or a number from 2 to a+b, provided that the aldehyde group of formula (1a) is in a form of an acetal with one of the hydroxy groups or the keto group of formula (1b) is in a form of an acetal with one of the hydroxy groups. The invention also relates to kits containing these ingredients, and use thereof for treating infections and wounds.

1 . A composition, comprising:
 octenidine or a pharmaceutical salt thereof;   a polyalcohol of formula (1a) or (1b):
   (H—C—OH) a (HO—C—OH) h (H—C—H) c (CHO)  (1a),
 
   (H—C—OH) 2 (HO—C—OH) 12 (H—C—H) c (CO)  (1b),
 
   wherein a, b, c are integers, wherein a+b is at least 2, c is 0, 1 or a number in a range of 2 to a+b,   the aldehyde group of formula (1a) is in a form of an acetal with one of the hydroxy groups or ene-er-mere the keto group of formula (1b) is in a form of an groups optionally as acetal with one of the hydroxy groups.   
     
     
         2 . A therapeutic administration kit comprising the composition of  claim 1 . 
     
     
         3 . A pharmaceutical composition, comprising the composition of  claim 1 . 
     
     
         4 . The composition according to  claim 1 , wherein the polyalcohol is a carbohydrate with the chemical formula 2: C n (H 2 O) m , wherein n is an integer of at least 3 and m is an integer in a range of n−15% to n+15% as a rounded integer. 
     
     
         5 . The composition according to  claim 1 , wherein the polyalcohol is uncharged. 
     
     
         6 . The composition according to  claim 1 , wherein the polyalcohol is a mono- or disaccharide or a deoxy- or mono-carboxylic acid derivative of a mono- or disaccharide. 
     
     
         7 . The composition according to  claim 1 , wherein the polyalcohol comprises an aldose or ketose. 
     
     
         8 . The composition according to  claim 1 , wherein the polyalcohol is selected from the group consisting of glucose, galactose, fructose, fucose, maltose, ribose, deoxyribose, deoxyglucose. 
     
     
         9 . The composition according to  claim 1 , wherein at least one of the polyalcohol and/or octenidine is in solution. 
     
     
         10 . The composition according to  claim 1 , wherein the polyalcohol is in solution and a concentration of the polyalcohol is from 0.01% to 12% (w/v), based on a volume of the solution. 
     
     
         11 . The composition according to  claim 1 , wherein the octenidine is in solution and a concentration of the octenidine is from 0.0001% to 1% (w/w). 
     
     
         12 . The composition according to  claim 1 , further comprising, in solution, NaCl in a concentration of under 0.1% (w/v), based on a volume of the solution. 
     
     
         13 . The composition according to  claim 1 , further comprising a gel or hydrogel as a carrier for the polyalcohol and/or the. 
     
     
         14 . (canceled) 
     
     
         15 . A pharmaceutical agent, comprising:
 octenidine or one of its pharmaceutically acceptable salts;
 a solvent; 
 glucose; and 
 optionally, a carrier; 
 wherein the concentration of the glucose is from 0.01% to 12% (w/v), and the concentration of octenidine is from 0.0001% to 1% (w/w). 
   
     
     
         16 . The composition of  claim 13 , wherein the carrier is a slow release carrier. 
     
     
         17 . The composition of  claim 1 , wherein the polyalcohol of formula 1 is fructose. 
     
     
         18 . A pharmaceutical agent, comprising:
 octenidine or one of its pharmaceutically acceptable salts;   a solvent;   fructose; and   optionally, a carrier;   wherein the concentration of fructose is from 0.01% to 12% (w/v), and   the concentration of octenidine is from 0.0001% to 1% (w/w).   
     
     
         19 . A composition, comprising:
 octenidine or a pharmaceutical salt thereof; and   a polyalcohol of formula (2):
   C n (H 2 O)  (2)
 
 wherein 
 n is an integer of at least 3 and m is an integer in a range of n−15% to n+15% as a rounded integer, and 
 the polyalcohol is a polyether or polyester comprising 2 to 6 cyclic acetal units. 
   
     
     
         20 . The composition of  claim 19 , wherein the polyalcohol of formula (2) is selected from the group consisting of saccharose, lactose and maltose. 
     
     
         21 . The composition of  claim 19  wherein the composition comprises a solvent and the composition is a solution. 
     
     
         22 . A wound dressing or a swab impregnated with a solution of the composition of  claim 1 .