US2015119585A1PendingUtilityA1

Sterol derivative

47
Assignee: KYOWA HAKKO KIRIN CO LTDPriority: Jul 24, 2009Filed: Dec 30, 2014Published: Apr 30, 2015
Est. expiryJul 24, 2029(~3 yrs left)· nominal 20-yr term from priority
Inventors:Kenji UchidaTsutomu AgatsumaKazuhiro HibinoSetsuya SashoKyoichiro IidaHideyuki Onodera
A61P 9/10A61P 9/00A61P 43/00A61P 25/08A61P 25/24A61P 25/16A61P 25/28A61P 25/22A61P 25/00A61P 25/18A61K 31/585C07J 73/003C07J 75/005C07J 9/00A61P 21/02C07J 73/008
47
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Claims

Abstract

The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; X a and X b are the same or different, and represent a bond or the like; R 1 , R 2 , R 3 , R 4 , R 7 and R 8 are the same or different, and represent a hydrogen atom or the like; R 5 and R 6 are the same or different, and represent a hydrogen atom or the like; R 9 represents a hydrogen atom or the like; R 10 and R 11 together represent a bond or the like; and R 12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.

Claims

exact text as granted — not AI-modified
1 - 16 . (canceled) 
     
     
         17 . A method for preparing a compound represented by the following formula (I-b): 
       
         
           
           
               
               
           
         
         comprising a step of converting a compound represented by the following formula (IV) to a compound represented by the following formula (V): 
       
       
         
           
           
               
               
           
         
         wherein, R 22  represents a protective group for a hydroxy group, Y represents an optionally substituted lower alkyl or an optionally substituted lower alkenyl, and   represents a single bond or a double bond. 
       
     
     
         18 . The method according to  claim 17 , wherein the formula (I-b) is the following formula (P) or (Q). 
       
         
           
           
               
               
           
         
       
     
     
         19 . The method according to  claim 17 , wherein the protective group for a hydroxy group is trimethyl silyl, tetrahydropyranyl or benzoyl. 
     
     
         20 . The method according to  claim 18 , wherein the protective group for a hydroxy group is trimethyl silyl, tetrahydropyranyl or benzoyl.

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