Conjugates comprising an n-oxime bond and associated methods

Abstract

Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least one reactive amide group, R″ is derived from a compound comprising at least one reactive aminooxy group, and X is H, C n H (n+2) or other atoms. Additional methods are also provided.

What is claimed is: 
     
         1 . A composition comprising a conjugate represented by the following Formula (I): 
       
         
           
           
               
               
           
         
         wherein R′ is derived from a first compound comprising at least one reactive amide group, R″ is derived from a second compound comprising at least one reactive aminooxy group, wherein the second compound is selected from the group consisting of a polymer, a polysaccharide, a saccharide, a nucleic acid and a small molecule, and X is H, C n H (n+2) . 
       
     
     
         2 . The composition of  claim 1  further comprising at least one additional N-oxime bond so as to form a crosslinked composition. 
     
     
         3 . The composition of  claim 1  wherein the first compound is selected from the group consisting of a polymer, a protein, a peptide, a polysaccharide, a saccharide, a nucleic acid and a small molecule. 
     
     
         4 . The composition of  claim 1  further comprising a pharmaceutically acceptable carrier. 
     
     
         5 . A composition comprising a conjugate represented by the following Formula (II): 
       
         
           
           
               
               
           
         
         wherein R′ is derived from a first compound comprising at least one reactive amide group, R″ is derived from a second compound comprising at least one reactive aminooxy group, wherein the second compound is selected from the group consisting of a polymer, a polysaccharide, a saccharide, a nucleic acid and a small molecule, and X is H, C n H (n+2) . 
       
     
     
         6 . The composition of  claim 5  further comprising at least one additional N-oxime bond so as to form a crosslinked composition. 
     
     
         7 . The composition of  claim 5  wherein the first compound is selected from the group consisting of a polymer, a protein, a peptide, a polysaccharide, a saccharide, a nucleic acid and a small molecule. 
     
     
         8 . The composition of  claim 5  further comprising a pharmaceutically acceptable carrier.