Compounds and Methods of Making Compounds

Abstract

Embodiments of the present disclosure provide for compounds and methods of making compounds such as those shown in FIGS. 1.1A and 1.1B having formula 2, 3, 4, 5, 11, and 12 and formula 2′, 4′, and 11′,as well as uses for the compounds for imaging, and the like.

What is claimed is: 
     
         1 . A method of imaging a T Cell comprising:
 administering to the subject a compound having formula 3; and   imaging the subject, wherein detecting the presence of the compound corresponds to the presence of the T cell, wheiren formula 3 is represented by the following structure,   
       
         
           
           
               
               
           
         
       
       wherein Ist is an isotope, wherein R′ is a compound having a formula selected from the group consisting of R′1, R′2, R′3, R′4, and R′5: 
       
         
           
           
               
               
           
         
       
     
     
         2 . The method of  claim 1 , wherein the compound having formula 3 is a compound having formula 12, 
       
         
           
           
               
               
           
         
       
     
     
         3 . The method of  claim 1 , wherein the isotope is selected from the group consisting of:  18 F,  131 I,  125 I,  124 I,  123 I,  121 I,  77 Br,  77 Br,  75 Br, and  75 Br. 
     
     
         4 . A method of imaging T lymphoblasts comprising:
 administering to the subject a compound including formula 3; and   imaging the subject, wherein detecting the presence of the compound corresponds to the presence of T lymphoblasts, wheiren formula 3 is represented by the following structure,   
       
         
           
           
               
               
           
         
       
       wherein Ist is an isotope, wherein R′ is a compound having a formula selected from the group consisting of R′1, R′2, R′3, R′4, and R′5: 
       
         
           
           
               
               
           
         
       
     
     
         5 . The method of  claim 4 , wherein the compound having formula 3 is a compound having formula 12, 
       
         
           
           
               
               
           
         
       
     
     
         6 . The method of  claim 4 , wherein the isotope is selected from the group consisting of  18 F,  131 I,  125 I,  124 I,  123 I,  121 I,  77 Br,  77 Br,  75 Br, and  75 Br.