Cancer cell-trapping metal filter, cancer cell-trapping metal filter sheet, cancer cell-trapping device, and manufacturing methods therefor

Abstract

Provided are a cancer cell-trapping metal filter which has a high opening ratio, a cancer cell-trapping metal filter sheet, a cancer cell-trapping device using the cancer cell-trapping filter, and manufacturing methods therefor. According to a cancer cell-trapping metal filter 1 , openings of connected through-holes 12 that are formed in a metal sheet 11 have a wave shape, and thus it is possible to extract a CTC from other components by utilizing a hole diameter on a short-side side of the openings, and it is possible to make the connected through-holes be closer to each other due to the wave shape while maintaining a CTC trapping ability. Accordingly, it is possible to further improve the opening ratio in the cancer cell-trapping metal filter 1.

1 . A cancer cell-trapping metal filter having a through-hole that is formed in a thickness direction of a metal sheet in which a main component is composed of a metal,
 wherein an opening of the through-hole has a wave shape.   
     
     
         2 . The cancer cell-trapping metal filter according to  claim 1 ,
 wherein a plurality of the through-holes are arranged.   
     
     
         3 . The cancer cell-trapping metal filter according to  claim 1 ,
 wherein an opening ratio of the opening is 10% to 50%.   
     
     
         4 . The cancer cell-trapping metal filter according to  claim 1 ,
 wherein a surface of the metal sheet is plated with gold.   
     
     
         5 . A cancer cell-trapping metal filter sheet, comprising:
 a plurality of filtration portions having a through-hole formed in a thickness direction of a metal sheet in which a main component is composed of a metal; and   a connection portion that is provided between two adjacent filtration portions that are included in the plurality of filtration portions,   wherein a plurality of the through-holes, which have an wave-shaped opening, are formed in the filtration portion.   
     
     
         6 . The cancer cell-trapping metal filter sheet according to  claim 5 ,
 wherein an opening ratio of the opening in the filtration portion is 10% to 50%.   
     
     
         7 . The cancer cell-trapping metal filter sheet according to  claim 5 ,
 wherein a positioning hole is formed in the connection portion.   
     
     
         8 . The cancer cell-trapping metal filter sheet according to  claim 5 ,
 wherein a surface of the metal sheet is plated with gold.   
     
     
         9 . A cancer cell-trapping device, comprising:
 a casing that includes a cover member which is formed from a light-transmitting resin material and which has an inlet channel from which a liquid to be tested is introduced to the inside of the casing, and an accommodation member that has an outlet channel through which the liquid to be tested is discharged to the outside of the casing; and   the cancer cell-trapping metal filter according to  claim 1  which is provided on a flow path inside the casing between the inlet channel and the outlet channel in such a manner that the liquid to be tested flows through the through-hole.   
     
     
         10 . The cancer cell-trapping device according to  claim 9 ,
 wherein a hole diameter of the through-hole in a main surface on an upstream side is smaller than a hole diameter on a rear surface side with respect to the main surface.   
     
     
         11 . The cancer cell-trapping device according to  claim 9 ,
 wherein instead of the cancer cell-trapping metal filter, a cancer cell-tapping metal filter member, which includes a filtration portion having a through-hole formed in a thickness direction of a metal sheet in which a main component is composed of a metal, and a connection portion having a positioning hole formed at the periphery of the filtration portion, is provided, and   at least one of the cover member and the accommodation member is provided with a protrusion that is inserted into the positioning hole at a position corresponding to the positioning hole when the cancer cell-trapping metal filter member is mounted.   
     
     
         12 . The cancer cell-trapping device according to  claim 9 ,
 wherein the cover member and the accommodation member are welded to each other.   
     
     
         13 . A method of manufacturing a cancer cell-trapping metal filter, comprising:
 a process of laminating a photoresist on metal foil;   a process of overlapping a photomask including a wave-shaped light-transmitting portion on the photoresist and exposing the photoresist;   a process of removing an uncured portion of the photoresist by development to form photoresist patterns;   a process of performing metal plating between the photoresist patterns to form metal plating patterns having a height lower than a height of the photoresist patterns;   a process of removing the metal foil by chemical dissolution to obtain a structure including the metal plating patterns and the photoresist patterns; and   a process of removing the photoresist patterns from the structure to obtain the metal plating patterns having a through-hole corresponding to the light-transmitting portion.   
     
     
         14 . The method of manufacturing a cancer cell-trapping metal filter according to  claim 13 ,
 wherein the metal foil is adhered to a carrier layer, and   the method further comprises a process of peeling the carrier layer after the process of forming the metal plating patterns.   
     
     
         15 . The method of manufacturing a cancer cell-trapping metal filter according to  claim 13 ,
 wherein an opening ratio of an opening is 10% to 50%.   
     
     
         16 . The method of manufacturing a cancer cell-trapping metal filter according to  claim 13 , further comprising:
 a process of plating a surface of the metal plating patterns with gold after the process of obtaining the metal plating patterns.   
     
     
         17 . A method of manufacturing a cancer cell-trapping metal filter sheet, comprising:
 a process of laminating a photoresist on metal foil;   a process of overlapping a photomask including a plurality of blocks of wave-shaped light-transmitting portions on the photoresist and exposing the photoresist;   a process of removing an uncured portion of the photoresist by development to form photoresist patterns;   a process of performing metal plating between the photoresist patterns to form metal plating patterns having a height lower than a height of the photoresist patterns;   a process of removing the metal foil by chemical dissolution to obtain a structure including the metal plating patterns and the photoresist patterns; and   a process of removing the photoresist patterns from the structure to obtain the metal plating patterns having a through-hole corresponding to the light-transmitting portion.   
     
     
         18 . The method of manufacturing a cancer cell-trapping metal filter sheet according to  claim 17 ,
 wherein the metal foil is adhered to a carrier layer, and   the method further comprises a process of peeling the carrier layer after the process of forming the metal plating patterns.   
     
     
         19 . The method of manufacturing a cancer cell-trapping metal filter sheet according to  claim 17 ,
 wherein in the process of overlapping the photomask on the photoresist and exposing the photoresist, a photomask, which includes a second light-transmitting portion different from the light-transmitting portion at the periphery of the blocks of the wave-shaped light-transmitting portions, is used.   
     
     
         20 . The method of manufacturing a cancer cell-trapping metal filter sheet according to  claim 17 ,
 wherein an opening ratio of an opening is 10% to 50%.   
     
     
         21 . The method of manufacturing a cancer cell-trapping metal filter sheet according to  claim 17 , further comprising:
 a process of plating a surface of the metal plating patterns with gold after the process of obtaining the metal plating patterns.   
     
     
         22 . A method of manufacturing a cancer cell-trapping device, comprising:
 a process of providing the cancer cell-trapping metal filter according to  claim 1  on a flow path inside a casing between an inlet channel and an outlet channel in such a manner that a hole diameter of the through-hole in a main surface on an upstream side becomes smaller than a hole diameter on a rear surface side with respect to the main surface, the casing including a cover member which is formed from a light-transmitting resin material and which has the inlet channel from which a liquid to be tested is introduced to the inside of the casing, and an accommodation member that includes the outlet channel through which the liquid to be tested is discharged to the outside of the casing.   
     
     
         23 . The method of manufacturing a cancer cell-trapping device according to  claim 22 ,
 wherein the cover member and the accommodation member are welded to each other.