Method and/or system for multicompartment analyte monitoring

Abstract

Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

What is claimed is: 
     
         1 . A method comprising:
 concurrently computing multiple estimators of a concentration of an analyte in a first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in a second physiological compartment; and   selecting one of said estimators for determining a patient therapy based, at least in part, on a performance metric, wherein said selected estimator is based, at least in part on a modeled latency in transportation of said analyte between said first and second physiological compartments.   
     
     
         2 . The method of  claim 1 , wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid. 
     
     
         3 . The method of  claim 1 , wherein said one or more measurements are obtained based, at least in part, on one or more values of a sensor signal, and wherein the modeled latency is based, at least in part, on an estimated rate of change in the sensor signal. 
     
     
         4 . The method of  claim 3 , wherein said sensor signal comprises a current responsive to the concentration of said analyte in said second physiological compartment. 
     
     
         5 . The method of  claim 1 , wherein the modeled latency is based, at least in part, on a latency of a presence of glucose in a patient's interstitial fluid to affect a blood glucose concentration in said patient. 
     
     
         6 . The method of  claim 1 , wherein said performance metric comprises a mean absolute relative difference between reference samples of said concentration of said analyte in the first physiological compartment and estimates of said concentration of said analyte in the first physiological compartment computed according to said selected estimator. 
     
     
         7 . The method of  claim 6 , wherein said selected estimator is based, at least in part, on a plurality of estimated parameters including an estimate of a latency in transportation of said analyte between said first and second physiological compartments. 
     
     
         8 . The method of  claim 1 , wherein said patient therapy comprises control of an insulin pump. 
     
     
         9 . An apparatus comprising:
 a sensor to generate a signal responsive to a concentration of an analyte in a second physiological compartment; and   a processor to:
 concurrently compute multiple estimators of a concentration of the analyte in a first physiological compartment based, at least in part, on one or more measurements of the concentration of the analyte in the second physiological compartment based, at least in part, on said signal; and 
 select one of said estimators for determining a patient therapy based, at least in part, on a performance metric, wherein said selected estimator is based, at least in part on a modeled latency in transportation of said analyte between said first and second physiological compartments. 
   
     
     
         10 . The apparatus of  claim 9 , wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid. 
     
     
         11 . The apparatus of  claim 9 , wherein said modeled latency is based, at least in part, on an estimated rate of change in said signal. 
     
     
         12 . The apparatus of  claim 11 , wherein said signal comprises a current responsive to the concentration of said analyte in said second physiological compartment. 
     
     
         13 . The apparatus of  claim 9 , wherein the modeled latency is based, at least in part, on a latency of a presence of glucose in a patient's interstitial fluid to affect a blood glucose concentration in said patient. 
     
     
         14 . The apparatus of  claim 9 , wherein said performance metric comprises a mean absolute relative difference between reference samples of said concentration of said analyte in the first physiological compartment and estimates of said concentration of said analyte in the first physiological compartment computed according to said selected estimator. 
     
     
         15 . The apparatus of  claim 14 , wherein said selected estimator is based, at least in part, on a plurality of estimated parameters including an estimate of a latency in transportation of said analyte between said first and second physiological compartments. 
     
     
         16 . The apparatus of  claim 9 , and further comprising an insulin pump, wherein the processor is further to control said insulin pump based, at least in part, on said determined patient therapy 
     
     
         17 . An article comprising:
 a non-transitory storage medium having machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to:   concurrently compute multiple estimators of a concentration of an analyte in a first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in a second physiological compartment; and   select one of said estimators for determining a patient therapy based, at least in part, on a performance metric, wherein said selected estimator is based, at least in part on a modeled latency in transportation of said analyte between said first and second physiological compartments.   
     
     
         18 . The article of  claim 17 , wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid. 
     
     
         19 . The article of  claim 17 , wherein said performance metric comprises a mean absolute relative difference between reference samples of said concentration of said analyte in the first physiological compartment and estimates of said concentration of said analyte in the first physiological compartment computed according to said selected estimator. 
     
     
         20 . The article of  claim 19 , wherein said selected estimator is based, at least in part, on a plurality of estimated parameters including an estimate of a latency in transportation of said analyte between said first and second physiological compartments.