Compositions and methods for treatment of vitiligo

Abstract

Compositions and methods are disclosed for treating vitiligo and promoting the formation of collagen.

What is claimed is: 
     
         1 . A method of treating vitiligo comprising topically administering to an affected area of a subject in need thereof a composition comprising a cosmeceutically acceptable medium and from about 0.1 to about 0.5 weight percent rapamycin to treat the subject. 
     
     
         2 . The method according to  claim 1 , wherein the composition further comprises fibroblast growth factor. 
     
     
         3 . The method according to  claim 2 , wherein the composition comprises from about 0.000015 to about 0.00005 weight percent fibroblast growth factor. 
     
     
         4 . The method according to  claim 1 , wherein the composition further comprises vitamin E. 
     
     
         5 . The method according to  claim 4 , wherein the composition comprises about 0.5 weight percent vitamin E. 
     
     
         6 . A method according to  claim 1 , wherein the composition further comprises tromethamine. 
     
     
         7 . A method according to  claim 6 , wherein the composition comprises about 0.5 weight percent tromethamine. 
     
     
         8 . A method according to  claim 1 , wherein the composition further comprises glutathione peroxidase. 
     
     
         9 . A method according to  claim 8 , wherein the composition comprises about 0.3 weight percent glutathione peroxidase. 
     
     
         10 . A method according to  claim 1 , wherein the composition further comprises catalase. 
     
     
         11 . A method according to  claim 10 , wherein the composition comprises about 0.3 weight percent catalase. 
     
     
         12 . A method according to  claim 1 , wherein the composition is a leave-on product. 
     
     
         13 . The method according to  claim 1 , wherein the composition is administered to the subject at least twice daily. 
     
     
         14 . The method according to  claim 1 , wherein about 0.25 mL of the composition is administered to the subject at least twice daily. 
     
     
         15 . The method according to  claim 1 , wherein about 0.35 mL of the composition is administered to the subject at least twice daily. 
     
     
         16 . A method of treating vitiligo comprising topically administering to an affected area of a subject in need thereof a composition comprising:
 a) a cosmeceutically acceptable medium;   b) from about 0.1 to about 0.5 weight percent rapamycin;   c) from about 0.000015 to about 0.00005 weight percent fibroblast growth factor;   d) from about 0.5 weight percent vitamin E;   e) from about 0.5 weight percent tromethamine;   f) from about 0.3 weight percent gluthione peroxidase; and   g) from about 0.3 weight percent catalase.