Foamable composition and uses thereof

Abstract

The present invention provides a safe and effective insecticide composition suitable for treating a subject infested with a parasitic anthropode or to prevent infestation by an arthropod. The insecticide composition is a foamable composition, including a first insecticide; at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 5%, or about 5% to about 10%;or about 10% to about 20%; or about 20% to about 50% by weight; about 0.1% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and (5) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

1 . (canceled) 
     
     
         2 . A composition comprising a carrier composition and a propellant, the carrier comprising:
 i. an active agent;   ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient, and mixtures of any two or more thereof, at a concentration of about 2% to about 50% by weight of the carrier composition;   iii. a foam adjuvant and a polymeric agent; and   iv. water;   wherein the propellant is a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the carrier composition; and wherein the polymeric agent is selected from the group consisting of bioadhesive agents, gelling agents, film forming agents, phase change agents, and mixtures of any two or more thereof.   
     
     
         3 . The composition of  claim 2 , wherein the active agent is an insecticide. 
     
     
         4 . The composition of  claim 2 , wherein the organic carrier is present at about 5% to about 50% by weight of the carrier composition and the foam adjuvant is present at about 0.1% to about 5% by weight of the carrier composition. 
     
     
         5 . The composition of  claim 2 , wherein the carrier composition is an emulsion. 
     
     
         6 . The composition of  claim 2 , further including about 0.1% to about 5% by weight of the carrier composition of a surface active agent. 
     
     
         7 . The composition of  claim 3 , wherein the insecticide is selected from the group consisting of an antibiotic insecticide, a botanical insecticide, a carbamate insecticide, a dinitrophenol insecticide, a fluorine insecticide, an insect growth regulator, a chitin synthesis inhibitor, a juvenile hormone mimics, a moulting hormone agonist, a moulting inhibitor, a nereistoxin analogue insecticide, a nicotinoid insecticide, a pyridylmethylamine insecticide, an organochlorine insecticide, a cyclodiene insecticide, an organophosphorus insecticide, an organophosphate insecticide, an organothiophosphate insecticides, an aliphatic amide organothiophosphate insecticide, an oxime organothiophosphate insecticide, a heterocyclic organothiophosphate insecticide, a benzothiopyran organothiophosphate insecticide, a benzotriazine organothiophosphate insecticide, an isoindole organothiophosphate insecticide, an isoxazole organothiophosphate insecticide, a pyrazolopyrimidine organothiophosphate insecticide, a pyridine organothiophosphate insecticide, a pyrimidine organothiophosphate insecticide, a quinoxaline organothiophosphate insecticide, a thiadiazole organothiophosphate insecticide, a triazole organothiophosphate insecticide, a phenyl organothiophosphate insecticides, a phosphonothioate insecticide, a phenyl ethylphosphonothioate insecticide, a phenyl phenylphosphonothioate insecticide, a phosphoramidate insecticide, a phosphoramidothioate insecticide, a phosphorodiamide insecticide, an oxadiazine insecticide, a phthalimide insecticide, a pyrazole insecticide, a pyrethroid insecticide, a pyrethroid ester insecticide, a pyrethroid ether insecticide, a pyrimidinamine insecticide, a pyrrole insecticide, a tetronic acid insecticide, a thiourea insecticide, a urea insecticide, and mixtures of any two or more thereof. 
     
     
         8 . The composition of  claim 2 , wherein the at least one active agent is selected from the group consisting of a steroidal antiinflammatory agent, an immunosuppressive agent, an immunomodulator, an immunoregulating agent, a hormonal agent, an antibiotic agent, an antifungal agent, an antiviral agent, an antiparasitic agent, vitamin A, a vitamin A derivative, vitamin B, a vitamin B derivative, vitamin C, a vitamin C derivative, vitamin D, a vitamin D derivative, vitamin E, a vitamin E derivative, vitamin F, a vitamin F derivative, vitamin K, a vitamin K derivative, a wound healing agent, a disinfectant, an anesthetic, an antiallergic agent, an alpha hydroxyl acid, lactic acid, glycolic acid, a beta-hydroxy acid, a protein, a peptide, a neuropeptide, a allergen, an immunogenic substance, a haptene, an oxidizing agent, an antioxidant, a dicarboxylic acid, azelaic acid, sebacic acid, adipic acid, fumaric acid, a retinoid, an antiproliferative agent, an anticancer agent, a photodynamic therapy agent, benzoyl chloride, calcium hypochlorite, magnesium hypochlorite, an anti-wrinkle agent, a radical scavenger, a metal, silver, a metal oxide, titanium dioxide, zinc oxide, zirconium oxide, iron oxide, silicone oxide, talc, carbon, an anti wrinkle agent, a skin whitening agent, a skin protective agent, a masking agent, an anti-wart agent, a refatting agent, a lubricating agent, and mixtures of any two or more thereof. 
     
     
         9 . The composition of  claim 2 , wherein the organic carrier comprises a potent solvent selected from the group consisting of propylene glycol, hexylene glycol, benzyl alcohol, terpene-ol, dimethyl isosorbide, a polyol, butanediol, diethylene glycol, terpenes, di-terpenes, tri-terpenes, limonene, dioxolane, dimethylformanide, dimethyl solfoxide, methyl dodecyl sulfoxide, ethyl oleate, ethyl caprylate, diisopropyl adipate, dimethylacetamide, N-methylpyrrolidone, N-hydroxyethylpyrrolidone, polyvinylpyrrolidone, dimethylacetamide, azone (1-dodecylazacycloheptan-2-one), 2-(n-nonyl)-1,3-dioxolane, isosorbide derivatives, glycofurol, ethoxydiglycol, and mixtures of any two or more thereof. 
     
     
         10 . The composition of  claim 6 , wherein the surface active agent is non-ionic or a combination of non-ionic and ionic surface active agents, wherein the ratio of non-ionic surface active agent to ionic surface active agent is about 6:1 or greater than 6:1. 
     
     
         11 . The composition of  claim 6 , wherein the organic carrier is a hydrophobic solvent and wherein the surface active agent is present at a concentration of about 0.1% to about 5% by weight of the carrier composition. 
     
     
         12 . The composition of  claim 2 , wherein the organic carrier is an organic polar solvent. 
     
     
         13 . The composition of  claim 2 , wherein the foam adjuvant is selected from the group consisting of a fatty alcohol having 15 or more carbons in their carbon chain, a fatty acid having 16 or more carbons in their carbon chain, fatty alcohols derived from beeswax, a fatty alcohol having at least one double bond, a fatty acid having at least one double bond, a branched fatty alcohol, a branched fatty acid, a fatty acid substituted with a hydroxyl group, cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, 1-triacontanol, hexadecanoic acid, stearic acid, arachidic acid, behenic acid, octacosanoic acid, 12-hydroxy stearic acid, and mixtures of any two or more thereof. 
     
     
         14 . The composition of  claim 2 , wherein the at least one polymeric agent selected from the group consisting of naturally-occurring polymeric materials, a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a carrageenin gum, an xanthan gum, a quince seed extract, a tragacanth gum, a guar gum, a starch, chemically modified starches, semi-synthetic polymeric materials, cellulose ethers, a hydroxyethyl cellulose, a hydroxypropyl cellulose, a methyl cellulose, a carboxymethyl cellulose,a methylhydroxyethylcellulose, hydroxypropyl methylcellulose, a hydroxyethyl carboxymethylcellulose, a carboxymethylcellulose, a hydroxypropyl guar gum, a soluble starch, cationic celluloses, cationic guars, synthetic polymeric materials, carboxyvinyl polymers, a polyvinylpyrrolidone, a polyvinyl alcohol, polyacrylic acid polymers, polymethacrylic acid polymers, polyvinyl acetate polymers, polyvinyl chloride polymers, polyvinylidene chloride polymers, acrylic acid/ethyl acrylate copolymers, carboxyvinyl polymers, a colloidal water-soluble polyalkenyl polyether crosslinked polymer of acrylic acid crosslinked with polyallyl sucrose or polyallyl pentaerythritol, carbomer 934, carbomer 940, carbomer 950, carbomer 980, carbomer 951, carbomer 981, silicon dioxide, a poloxamer, and mixtures of any two or more thereof. 
     
     
         15 . The composition of  claim 2 , wherein the active agent is selected from the group consisting of niacinamide, tazarotene, azelaic acid, permethrin, and mixtures of any two or more thereof. 
     
     
         16 . The composition of  claim 4 , wherein the at least one organic carrier is selected from the group consisting of caprylic/capric triglyceride, isopropyl myristate, cyclomethicone, dimethicone, castor oil, oleyl alcohol, diisopropyl adipate, mineral oil, and mixtures of any two or more thereof. 
     
     
         17 . The composition of  claim 2 , further comprising an excipient selected from the group consisting of a stabilizing agent, an antioxidant, a humectant, a preservative, a colorant, an odorant, and mixtures of any two or more thereof. 
     
     
         18 . The composition of  claim 3 , wherein the insecticide is capable of treating or alleviating a disorder involving an anthropod or parasite. 
     
     
         19 . The composition of  claim 2 , wherein the active agent is water soluble, oil soluble, or both. 
     
     
         20 . The composition of  claim 2 , wherein the carrier composition does not form an impermeable occlusive barrier. 
     
     
         21 . The composition of  claim 2 , wherein the carrier composition comprises less than 5% or about 5% by weight of lower alcohols.