Compounds and Compositions for the Detection and Treatment of Alzheimer's Disease and Related Disorders

Abstract

One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

We claim: 
     
         1 . A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
     
     
         2 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of  claim 1 . 
     
     
         3 . A method for amyloid imaging a subject suffering from an amyloidosis-associated pathological condition comprising the step of:
 administering a diagnostically effective amount of   
       
         
           
           
               
               
           
         
       
     
     
         4 . The method of  claim 3 , wherein the amyloidosis-associated pathological condition is Alzheimer's disease. 
     
     
         5 . A method for treating a subject suffering from an amyloidosis-associated pathological condition, comprising the step of:
 administering a therapeutically effective amount of a compound of  claim 1 .   
     
     
         6 . The method of  claim 5 , wherein the amyloidosis-associated pathological condition is Alzheimer's disease. 
     
     
         7 . The method of  claim 5 , wherein the compound is