Topical compositions containing nitro fatty acids

Abstract

Activated fatty acids, topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.

1 . A topical composition comprising:
 at least one activated fatty acid; and   dermatologically acceptable vehicle.   
     
     
         2 . A method comprising applying the topical composition of  claim 1  to the skin of a patient in need of treatment. 
     
     
         3 . The method of  claim 2 , further comprising treating inflammation in the skin of a patient in need of treatment. 
     
     
         4 . A composition for the prevention of skin damage comprising: an effective amount of a nitroalkene in a dermatologically acceptable non-polar carrier. 
     
     
         5 . A method for the prevention and treatment of skin damage comprising: topically applying a composition containing an effective amount of a nitroalkene in a dermatologically acceptable non-polar carrier to damaged skin tissue. 
     
     
         6 . The method of  claim 5 , wherein the nitroalkene is nitro-linoleic acid, nitro-oleic acid, nitrated arachidonic acid, or nitrated cholesteryl lineolate. 
     
     
         7 . The method of  claim 5 , wherein the nitroalkene is present in a weight percentage which is within one of the following ranges:
 0.01%-0.025%;   0.025%-0.05%;   0.05%-0.10%;   0.10%-0.50%;   0.50%-1.0%;   0.025%-0.50%;   0.025%-1.0%;   1.0%-2.0%;   2.0%-5.0%;   5.0%-10.00%   1.0%-5.0%;   1.0%40.0%;   10.0%-20.0%;   20.0%-30.0%;   30.0%-40.0%;   40.0%-50.0%;   50.0%-60.0%;   60.0%-70.0%;   70.0%-80.0%;   80.0%-90.0%;   90.0%-98.0%;   10.0%-30.0%;   20.0%-40.0%;   30.0%-60.0%;   40.0%-70.0%;   50.0%-80.0%;   10.0%-50.0%;   10.0%-98.0%;   50.0%-70.0%;   50.0%-98.0%; or   70.0%-98.0%.   
     
     
         8 . The method of  claim 5 , wherein the non-polar carrier comprises one or more of: polyethylene glycols, glycerides, glycerin; polypropylene glycol; PVM/MA decadiene crosspolymer; hydrogenated polyisobutane/polyethane; isododecane; tetrahexyldecyl ascorbate; Vitamin E; beta carotene; disopropyl adipate; 2-ethylhexyl pentate; oleth-3; propanoic acid 2-hydroxy-dodecyl ester; propanoic acid, 2-hydroxy-, C12-15-alkyl esters; glycereth-4; glycereth-7; diglycerin; panthenol; and phytantriaol. 
     
     
         9 . The method of  claim 8 , wherein the non-polar carrier comprises one or more polyethylene glycols. 
     
     
         10 . The method of  claim 8 , wherein the skin inflammation is one or more of: acne, aging skin, alopecia, dermatitis, xerosis, eczema, rosacea, seborrhea, and psoriasis. 
     
     
         11 . The method of  claim 5 , wherein the non-polar carrier comprises a polymer polyether. 
     
     
         12 . The method of  claim 5 , wherein the carrier further comprises a phosphatidylcholine. 
     
     
         13 . The method of  claim 5 , wherein said composition further comprises one or more additional ingredients selected from the group consisting of: fatty acid esters of ascorbic acid, lipoic acid, and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienol or tocotrienol derivatives. 
     
     
         14 . The method of  claim 5 , wherein the skin damage is one or more of: cut, abrasion, burn, blemish, cutaneous scar tissue, lesion, acne, aging skin, alopecia, dermatitis, xerosis, eczema, rosacea, seborrhea, and psoriasis; or skin inflammation.