Bioactive complex compositions and methods of use thereof

Abstract

A bioactive complex composition having enhanced oxidative stability, emulsion stability, mineral rich transparent beverages and a wide range of functional health benefits. The composition may include as a base composition individual ingredients or a synergistic blend of mineral salts, Omega-3 rich oils, phospholipids, chitosan, and alpha-casein, beta-casein, kappa-casein or protein fragments, glycopeptides, phosphopeptides. The composition may optionally be further utilized for the prevention of hypercholesterolemia, bone (and teeth) mineral loss, treatment of mental health diseases, heart health, additional nutritional supplementation, and treatment of additional medical conditions.

1 . A bioactive composition comprising a polycationic protein or protein fragment complex whereby the complex is operable as an electron transfer bridge. 
     
     
         2 . The composition according to  claim 1 , whereby the complex and electron transfer bridge are within an oil and water emulsion with a water phase and whereby the oil phase is comprised of at least one selected from the group consisting of reducing sugar including glucose, cyclodextrin, or combinations thereof, fat soluble vitamins, Omega-3 rich oils, fat-soluble nutraceutical or pharmaceutical actives, oils rich in ferulic acid including olive, rice bran, corn, or oat oils, ionic liquids, ionic emulsifiers, monoglycerides, diglycerides, or combinations thereof. 
     
     
         3 . The composition according to  claim 2 , whereby the oil phase is further comprised of chelating agents including EDTA, lactoferrin, phytic acid, cyclodextrin, permeation enhancers, or combinations thereof. 
     
     
         4 . The composition according to  claim 2 , whereby the water phase is comprised of at least one selected from the group consisting of lactoferrin, phytic acid, trehalose, acetyl L-carnitine, permeation enhancers, or combinations thereof. 
     
     
         5 . The composition according to  claim 3 , whereby the oil to cyclodextrin ratio is at least 10:1. 
     
     
         6 . The composition according to  claim 1 , whereby the electron transfer bridge pH is adjusted to a pH between 5.5 and 6.5 by means including potassium hydroxide, calcium hydroxide, magnesium hydroxide, or combinations thereof. 
     
     
         7 . The composition according to  claim 1 , whereby the complex is further comprised of at least one selected from the group consisting of electron donor transfer, nucleotides including pyrimidines, nucleosides, ribose, cyclodextrin, antioxidants, Omega-3 rich oils, beta-glucan, or combinations thereof. 
     
     
         8 . The composition according to  claim 1 , whereby the electron transfer bridge is comprised of at least on selected from the group consisting of canola protein isolate, canola protein fragment, keratin, keratin, or combinations thereof complexed with at least one from the group consisting of chitosan, caseinophosphopeptide, or combinations thereof. 
     
     
         9 . The composition according to  claim 1 , whereby the electron transfer bridge is within an oil in water emulsion that is further comprised of a polycationic chitosan void of iron. 
     
     
         10 . The composition according to  claim 2 , whereby the composition is further comprised of electron transfer mediators including potassium salts, lactic acid salts, derivatives of potassium salts, derivatives of lactic acid salts, and combinations thereof. 
     
     
         11 . The composition according to  claim 1 , whereby the composition is an efficacious means for hypercholesterolemia prevention products, bone mineral loss prevention products, enhancing cognitive performance, reducing disorders of mental health, reducing triglyceride levels, reducing blood pressure levels, reducing arterial plaque, increasing free electron flow in an aqueous room temperature electride solution or combinations thereof. 
     
     
         12 . A bioactive composition having reduced susceptibility to oxidation comprised of an oil phase having a low electrical resistance pathway from the oil to the antioxidant whereby free radicals seek an electron from the antioxidant rather than damaging the lipid molecules within the oil phase. 
     
     
         13 . The composition according to  claim 12 , whereby the composition is further comprised of at least one selected from the group consisting of ionic emulsifiers, absorbed carbon dioxide, polyphenols, lactic acid, lactic acid derivatives, gallic acid, gallic acid derivatives, carnosic acid, carnosic acid derivatives, green tea extracts, chelators including EDTA, synthetic antioxidants including BHA, BHT, and TBHQ, oils having Omega-3, Omega-6, and Omega-9 fractions, oils rich in ferulic acid, oils rich in phytic acid, lactoferrin, antioxidants, galactolipids, cyclodextrin, or combinations thereof. 
     
     
         14 . The composition according to  claim 12 , whereby the cyclodextrin encapsulates at least one selected from the group consisting of coenzyme Q10, mixed tocopherols, mixed tocotrienols, oil soluble antioxidants, or combinations thereof. 
     
     
         15 . The composition according to  claim 12 , whereby the composition is further comprised of non-ionic surface active agents within the oil and water interface. 
     
     
         16 . A bioactive composition comprised of at least one complex selected from the group consisting of proteins, peptides, amino acids, or combinations thereof salted-in with at least one selected from the group consisting of lactic acid mineral salts, lactic acid derivatives, potassium salts, potassium derivatives, or combinations thereof. 
     
     
         17 . The composition according to  claim 16 , wherein the bioactive complex is further comprised of mineral salts salted in for means including enhanced solubilization, reduced bitterness, controlled saltiness, or combinations thereof. 
     
     
         18 . The composition according to  claim 16 , whereby the composition is further comprised of at least one selected from the group consisting of polycationic chitosan, phosphate buffering agent, citric acid, phytic acid, gallic acid, lactic acid, or combinations thereof. 
     
     
         19 . The composition according to  claim 16 , whereby the composition is further complexed with chitosan as a means to reduce bitterness. 
     
     
         20 . (canceled)