Using Heavy Water as a Contrast Agent for Hydrogen Magnetic Resonance Imaging
Abstract
A method of using an imaging contrast agent is provided for hydrogen magnetic resonance imaging (H MRI). The agent uses replacement and chemical exchange of hydrogen (H) and deuterium (D) on obtaining MRI images for comparison. An isotonic physiologic saline solution with deuterium oxide (D 2 O) is made. The solution is intravenously injected to obtain the intensity alterations on MRI images. The injected D 2 O is perfused into tissue and replace the original water. Exchanges between H and D occur and a solution of hydrogen deuterium oxide (HDO) is obtained. After such mechanisms, MRI images are compared for differences. Thus, a novel, non-radioactive, non-toxic and non-invasive MRI agent is provided for people who are allergic to general imaging agents.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A method of providing a fast, non-radioactive, non-toxic and non-invasive imaging contrast agent for use in perfusion MRI, comprising:
administering heavy water (deuterium oxide, D 2 O) as a contrast agent of hydrogen magnetic resonance imaging (MRI); and indirectly detecting the deuterium (D) by measuring the difference of signal intensities of hydrogen ( 1 H) before and after administration of D 2 O.
2 . The method according to claim 1 , wherein said imaging contrast agent is produced by the method comprising:
(a) preparing isotonic physiologic saline by sodium chloride and D 2 O; (b) putting said solution of D 2 O into a living object through intravenous injection; (c) scanning said living object through MRI; and (d) obtaining changes of brightness and contrast in images of said living object.
3 . The method according to claim 2 , wherein, on obtaining said changes of brightness and contrast, two mechanisms occur; the replacement of H with injected D, and a chemical exchange reaction between D 2 O and H 2 O as follows:
H
2
O
+
D
2
O
2
H
D
O
,
K
=
[
H
D
O
]
2
[
H
2
O
]
[
D
2
O
]
;
wherein
K is an equilibrium constant.
4 . The method of claim 2 , wherein the D 2 O is injected into said living object at an amount of 0.1˜20% of weight of said living object.
5 . The method of claim 1 , wherein the sensitivity of indirect detection of D 2 O is up to 100 times higher than the direct detection.Join the waitlist — get patent alerts
Track US2015086485A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.