Combination of 4- benzamide and a nmda receptor antagonist and pharmaceutical compositions containing the same

Abstract

Combination between 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, and an NMDA glutamatergic receptor antagonist. Medicinal products containing the same which are useful in the treatment of cognitive disturbances associated with cerebral ageing and neurodegenerative diseases.

1 -A method of treating a condition selected from cognitive disturbances associated with cerebral aging and cognitive disturbances associated with neurodegenerative diseases in a subject in need thereof, comprising administration of a combination comprising 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide of formula (I): 
       
         
           
           
               
               
           
         
         or an addition salt thereof with a pharmaceutically acceptable acid or base, and an NMDA glutamatergic receptor antagonist. 
       
     
     
         2 -The method of claim  1 , wherein the condition is cognitive disturbances associated with Alzheimer's disease. 
     
     
         3 -The method of claim  2 , wherein the NMDA glutamatergic receptor antagonist is memantine or a pharmaceutically acceptable salt thereof. 
     
     
         4 -The method of claim  3 , wherein the NMDA glutamatergic receptor antagonist is memantine hydrochloride. 
     
     
         5 -The method of claim  1 , wherein the 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide is in the form of an oxalate or hydrochloride. 
     
     
         6 -The method of claim  1 , wherein (i) the 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide is administered at a daily dose of 2 mg, 5 mg or 20 mg (expressed in terms of base equivalent) in the form of a hydrochloride, and (ii) the NMDA glutamatergic receptor antagonist is memantine hydrochloride administered at a daily dose of 10 mg or 20 mg.