Methods of using sustained release aminopyridine compositions

Abstract

A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.

1 - 20 . (canceled) 
     
     
         21 . A method of improving walking in a human multiple sclerosis patient in need thereof comprising orally administering to said patient a sustained release composition of 10 milligrams of 4-aminopyridine twice daily, without a prior period of 4-aminopyridine titration or a subsequent period of 4-aminopyridine titration. 
     
     
         22 . A method of increasing walking speed in a human multiple sclerosis patient in need thereof comprising orally administering to said patient a sustained release composition of 10 milligrams of 4-aminopyridine twice daily, without a prior period of 4-aminopyridine titration or a subsequent period of 4-aminopyridine titration. 
     
     
         23 . The method according to  claim 21  wherein the administering is for at least 2 weeks. 
     
     
         24 . The method according to  claim 22  wherein the administering is for at least 2 weeks. 
     
     
         25 . The method according to  claim 21  wherein the administering is for at least 12 weeks. 
     
     
         26 . The method according to  claim 22  wherein the administering is for at least 12 weeks 
     
     
         27 . The method according to  claim 21  wherein the sustained release composition is a tablet. 
     
     
         28 . The method according to  claim 22  wherein the sustained release composition is a tablet.