Pharmaceutical composition comprising a mixture of carboxylated oligopeptides

Abstract

A pharmaceutical composition comprising a mixture of carboxylated oligopeptides, derived by hydrolysis of eukaryotic or prokaryotic cells and their subsequent partial carboxylation through acylation or alkylation of the amino acid and basic amino acid residues in the amino terminal structure of the oligopeptides. The resulting pharmaceutical composition can be used in production of medical drugs effective in the treatment of cancer, pancreatitis, viral infection, for the development of vaccines.

1 . A pharmaceutical composition, comprising a mixture of carboxylated oligopeptides, produced by enzymatic hydrolysis of natural polypeptides, that resulted in a oligopeptide mixture ranging of 2 to 30 amino acid residues, having free amino groups in the oligopeptide mixture and then carboxylated. 
     
     
         2 . The composition of  claim 1 , wherein the natural polypeptides is a protein derived from eukaryotic cell. 
     
     
         3 . The composition of  claim 1 , wherein the natural polynucleotide is a protein derived from procaryotic cell. 
     
     
         4 . The composition of  claim 1 , wherein the enzymatic hydrolysis of the natural polypeptides is provided by protease. 
     
     
         5 . The composition of  claim 1 , wherein the carboxylation of aminoacid residues with free amino groups is calculated through a mass modifier (Mm) on weighed portion of dry mixture of oligopeptides: 
       
         
           
             
               Mm 
               = 
               
                 
                   M 
                   r 
                   m 
                 
                  
                 
                   
                     n 
                      
                     
                         
                     
                      
                     
                       2 
                       
                         ( 
                         
                           n 
                           - 
                           1 
                         
                         ) 
                       
                     
                   
                   
                     ( 
                     
                       
                         2 
                         n 
                       
                       - 
                       1 
                     
                     ) 
                   
                 
               
             
           
         
         n- Quantity of the amino acid residues having free amino groups, available for modification of the taken weighed portion of dry oligopeptides composition 
         M m   I - Molecular weight of the modifier g/mol. 
       
     
     
         6 . The composition of  claim 1 , wherein the carboxylation of aminoacid residues is acylation by succinic anhydride. 
     
     
         7 . The composition of  claim 1 , wherein the carboxylation of aminoacid residues is alkylation by monochloroacetic acid.