Use of lipid conjugates in the treatment of disease

Abstract

This invention provides a method of preventing or treating a dermatologic condition including, inter alia, psoriasis, contact dermatitis, and atopic dermatitis, in a subject, the method includes the step of administering to said subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.

What is claimed is: 
     
         1 . A method of treating a dermatologic condition in a human subject, comprising the step of administering to said subject a composition comprising a compound represented by the structure of the general formula (I): 
       
         
           
           
               
               
           
         
         wherein 
         R 1  is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 carbon atoms; 
         R 2  is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 carbon atoms; 
         Y is nothing or a spacer group ranging in length from 2 to 30 atoms; 
         X is a polysaccharide; and 
         n is a number from 2 to 1000. 
       
     
     
         2 . The method according to  claim 1 , wherein R 1  and R 2  are both palmitoyl moieties. 
     
     
         3 . The method according to  claim 1 , wherein R 1  and R 2  are both myristoyl moieties. 
     
     
         4 . The method according to  claim 1 , wherein said dermatologic condition is psoriasis. 
     
     
         5 . The method according to  claim 1 , wherein said dermatologic condition is contact dermatitis. 
     
     
         6 . The method according to  claim 1 , wherein said dermatologic condition is atopic dermatitis. 
     
     
         7 . The method according to  claim 1 , wherein said polysaccharide is alginate. 
     
     
         8 . The method according to  claim 1 , wherein said polysaccharide is carboxymethylcellulose. 
     
     
         9 . The method according to  claim 1 , wherein said polysaccharide is dextran. 
     
     
         10 . The method according to  claim 1 , wherein n is a number from 2 to 100. 
     
     
         11 . The method according to  claim 1 , wherein the molecular weight of said polysaccharide is from 1-2,000 kDa.