Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent

Abstract

The present invention provides a medicament that suppresses (or mitigates) various neurological symptoms caused by a peripheral nerve disorder induced by an anti-cancer agent.

1 . A method for suppressing a peripheral nerve disorder induced by an anti-cancer agent, which comprises administering a compound represented by the formula (II): 
       
         
           
           
               
               
           
         
         wherein 
         R 1′  is 
         (1) an aliphatic hydrocarbon group optionally having substituent(s), 
         (2) an aromatic hydrocarbon group optionally having substituent(s), 
         (3) a heterocyclic group optionally having substituent(s), 
         (4) a group represented by the formula: —OR 1a′  wherein R 1a′  is a hydrogen atom or an aliphatic hydrocarbon group optionally having substituent(s), or 
         (5) a group represented by the formula: 
       
       
         
           
           
               
               
           
         
         wherein R 1b′  and R 1c′  are the same or different and each is a hydrogen atom or an aliphatic hydrocarbon group optionally having substituent(s), 
         X is methylene, NH, a sulfur atom or an oxygen atom, 
         Y is methylene optionally having substituent(s) or NH optionally having substituent(s), 
         ring A′ is a 5- to 8-membered ring optionally having 1 to 4 substituents selected from the group consisting of 
         (i) an aliphatic hydrocarbon group optionally having substituent(s), 
         (ii) an aromatic hydrocarbon group optionally having substituent(s), 
         (iii) a group represented by the formula: —OR 2′  wherein R 2′  is a hydrogen atom or an aliphatic hydrocarbon group optionally having substituent(s), and 
         (iv) a halogen atom, 
         Ar′ is an aromatic hydrocarbon group optionally having substituent(s), 
         a group represented by the formula: 
       
       
         
           
           
               
               
           
         
         is a group represented by the formula: 
       
       
         
           
           
               
               
           
         
         s is an integer of 0 to 2, 
         t is an integer of 1 to 3, and 
         the total of s and t is 4 or less; 
         provided that when X is methylene, then Y should be methylene 
         optionally having substituent(s), 
         or a salt thereof or a prodrug thereof.