US2015045386A1PendingUtilityA1

(2s,3r)-n-2-3-pyridinylmethyl-1-azabicyclo 2.2.2 oct-3-yl benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

Assignee: TARGACEPT INCPriority: Aug 2, 2007Filed: Aug 25, 2014Published: Feb 12, 2015
Est. expiryAug 2, 2027(~1 yrs left)· nominal 20-yr term from priority
A61P 3/04A61P 43/00A61P 35/00A61P 9/10A61P 9/00A61P 3/06A61P 9/14A61P 3/00A61P 25/26A61P 3/10A61P 25/16A61P 25/14A61P 25/04A61P 25/02A61P 25/22A61P 25/18A61P 25/28A61P 25/00A61P 29/00A61P 25/24A61P 21/00A61K 31/439C07B 2200/07A61K 31/4545C07D 405/14C07D 453/02
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Claims

Abstract

The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

Claims

exact text as granted — not AI-modified
1 . A method for treating a neurodegenerative disorder comprising administering a compound (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof, substantially free of (2S,3S)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, (2R,3S)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, (2R,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, and pharmaceutically acceptable salts thereof. 
     
     
         2 . The method of  claim 1 , wherein the treatment is for dementia. 
     
     
         3 . The method of  claim 1 , wherein the treatment is for ataxia.

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