Thiophene-carboxamides useful as inhibitors of protein kinases

Abstract

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

1 . A compound of formula I: 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is H; 
 G is —O—; 
 L is C 0-3 alkyl optionally substituted with 0-3 J L ; 
 Ring A is 
 
       
         
           
           
               
               
           
         
       
       Ring A is optionally substituted with 0-3 J A ;
 Ring B is phenyl optionally substituted with 0-5 J B ; 
 Ring B′ is a 5-8 membered aromatic or nonaromatic monocyclic ring containing 0-3 heteroatoms selected from O, N, and S; Ring B′ is optionally substituted with 0-4 J B′ ; 
 each J A  and J B  is independently H, unsubstituted C 1-6 alkyl, halo, NO 2 , CN, OH, OR, SH, SR, NH 2 , NHR, N(R) 2 , COH, COR, CONH 2 , CONHR, CONR 2 , NHCOR, NRCOR, NHCONH 2 , NHCONHR, NHCON(R) 2 , SO 2 NH 2 , SO2NHR, SO2N(R) 2 , NHSO 2 R, or NRSO 2 R; 
 each J L  and J Z  is independently H, halo, unsubstituted C 1-6 alkyl NO 2 , CN, —NH 2 , —OH, or —CO 2 H; and 
 R is H. 
 
     
     
         2 - 11 . (canceled) 
     
     
         12 . The compound of  claim 1 , wherein J A  is H. 
     
     
         13 - 14 . (canceled) 
     
     
         15 . A compound having the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         16 . A composition comprising a compound of any one of  claim 1 ,  12 , or  15 , and a pharmaceutically acceptable carrier, adjuvant, or vehicle. 
     
     
         17 - 33 . (canceled)