US2015037378A1PendingUtilityA1

Anti-Microbial Formulations Containing Nitric Oxide

69
Individually held — no corporate assignee on recordPriority: Jun 30, 2003Filed: Oct 20, 2014Published: Feb 5, 2015
Est. expiryJun 30, 2023(expired)· nominal 20-yr term from priority
Inventors:Gerald M. Rosen
A61K 8/02A61K 41/00A61K 47/32A61K 33/26A61K 9/7007A61K 9/0063A61K 9/006A61K 31/295A61K 8/40A61K 9/7023A61K 33/00A61Q 11/00A61K 47/6955A61K 9/0056A61K 8/19
69
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Claims

Abstract

Compositions and methods are directed to antimicrobial compositions and articles that release .NO from the composition and/or article in an amount effective to act as a microbicide. Preferred .NO-releasing compositions include a nitrosyl-containing organometallic compound, and can be encapsulated in gels or topical coatings.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . An antimicrobial composition comprising:
 an .NO generating compound encapsulated within a biodegradable polymer formulated for use as a drug delivery system,   wherein the .NO generating compound decomposes to release .NO in an amount effective to have microbicidal activity.   
     
     
         2 . The antimicrobial composition of  claim 1 , wherein the biodegradable polymer is formulated to form a gel. 
     
     
         3 . The antimicrobial composition of  claim 1 , wherein the antimicrobial composition comprises a coating, and wherein the coating is configured to be directly applied to human tissue. 
     
     
         4 . The antimicrobial composition of  claim 1 , wherein the .NO generating compound is a nitrosyl-containing organometallic compound. 
     
     
         5 . The antimicrobial composition of  claim 4 , wherein the nitrosyl-containing organometallic compound is present at 0.1 μmole to 100 μmoles. 
     
     
         6 . The antimicrobial composition of  claim 4 , wherein the nitrosyl-containing organometallic compound comprises a chelating agent. 
     
     
         7 . The antimicrobial composition of  claim 1 , wherein the biodegradable polymer includes at least one member of the group consisting of gelatin, albumin, casein, fibrin, polylactide, polyglycocide, polyalkylene oxide, and polyvinyl chloride. 
     
     
         8 . The antimicrobial composition of  claim 1 , wherein the .NO generating compound decomposes to generate an amount of .NO effective as a bactericide. 
     
     
         9 . A method of providing antimicrobial activity to human tissue comprising:
 providing an .NO generating compound encapsulated within a biodegradable polymer formulated for use as a drug delivery system;   applying the encapsulated .NO generating compound encapsulated within the biodegradable polymer as a coating to a human tissue; and   allowing the .NO generating compound to decompose to generate an amount of .NO effective as a microbicide.   
     
     
         10 . The method of  claim 9 , wherein the biodegradable polymer is formulated to form a gel. 
     
     
         11 . The method of  claim 9 , wherein the .NO generating compound is a nitrosyl-containing organometallic compound. 
     
     
         12 . The method of  claim 11 , wherein the nitrosyl-containing organometallic compound is present at 0.1 μmole to 100 μmoles. 
     
     
         13 . The method of  claim 11 , wherein the nitrosyl-containing organometallic compound comprises a chelating agent. 
     
     
         14 . The method of  claim 9 , wherein the biodegradable polymer includes at least one member of the group consisting of gelatin, albumin, casein, fibrin, polylactide, polyglycocide, polyalkylene oxide, and polyvinyl chloride. 
     
     
         15 . The method of  claim 9 , wherein the decomposition of the .NO generating compound is modulated by exposure to light. 
     
     
         16 . The method of  claim 9 , wherein the .NO generating compound decomposes to generate an amount of .NO effective as a bactericide.

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