Substituted cellulose acetates and uses thereof

Abstract

The present invention relates to substituted cellulose acetates and methods of use thereof. One embodiment of the present invention provides a coating having a substituted cellulose acetate having a polar substituent that has an oxygen atom covalently bonded to a nonmetal selected from the group of sulfur, phosphorus, and boron; wherein the nonmetal is present in at least about 0.01% by weight of the substituted cellulose acetate.

What is claimed: 
     
         1 . A coated pharmaceutical composition comprising:
 a pharmaceutical composition having a coating that comprises a substituted cellulose acetate comprising a polar substituent that comprises an oxygen atom covalently bonded to a nonmetal selected from the group consisting of: sulfur, phosphorus, boron, and chlorine; wherein the nonmetal is present in at least about 0.01% by weight of the substituted cellulose acetate.   
     
     
         2 . The coated pharmaceutical composition of  claim 1 , wherein the nonmetal is present in no more than about 25% by weight of the substituted cellulose acetate. 
     
     
         3 . The coated pharmaceutical composition of  claim 1 , wherein the pharmaceutical composition comprises a pharmaceutical composition selected from the group consisting of: an analgesic, an anti-inflammatory agent, an anti-arrhythmic agent, an anti-asthma agent, an anti-bacterial agent, an anti-viral agent, an anti-coagulant, an anti-dementia agent, an anti-depressant, an anti-diabetic, an anti-hypertensive agent, an anti-malarial, an anti-migraine agent, an anti-muscarinic agent, an anti-neoplastic agent, an immunosuppressant, an anti-protozoal agent, an anti-thyroid agent, an anti-tussive, an anxiolytic, a sedative, a hypnotic, a neuroleptic, a neuro-protective agent, a beta blocker, a cardiac inotropic agent, a cell adhesion inhibitor, a corticosteroid, a cytokine receptor activity modulator, a diuretic, an anti-parkinsonian agent, a gastrointestinal agent, a histamine H-receptor antagonist, a keratolytic, a lipid regulating agent, a muscle relaxant, a nitrate, an anti-fungal agent, an anti-anginal agent, a non-steroid anti-asthma agent, a nutritional agent, a sex hormone, a stimulant, an anti-erectile dysfunction agent, an anesthetic, an antihistamine, a decongestant, a cough suppressant, a demulcent, an expectorant, and any combination thereof. 
     
     
         4 . The coated pharmaceutical composition of  claim 1 , wherein the pharmaceutical composition comprises a pharmaceutical composition selected from the group consisting of: pseudoephedrine, phenylpropanolamine, phenylephrine, ephedrine, dextromethorphan, chlorphedianol, carbetapentane, caramiphen, noscapine, diphenhydramine, codeine, menthol, hydrocodone, hydromorphone, fominoben, glyceryl guaiacolate, terpin hydrate, ammonium chloride, N-acetylcysteine, bromhexine, ambroxol, chlorpheniramine, brompheniramine, dexchlorpheniramine, dexbrompheniramine, tripolidine, azatadine, doxylamine, tripelennamine, cyproheptadine, hydroxyzine, elemastine, carbinoxamine, phenindamine, bromodiphenhydramine, pyilamine, acrivastine, AHR-11325, astemizole, azelastine, cetirizine, ebastine, ketotifen, lodoxamide, loratidine, levocabastine, mequitazine, oxatomide, setastine, tazifylline, temelastine, terfenadine, terbutaline, atropine, aminophylline, epinephrine, isoprenaline, metaproterenol, bitoterol, theophylline, albuterol, aspirin, acetaminophen, ibuprofen, naproxen, phenol, benzocaine, hexyl resorcinol, dyclonine, pharmaceutically acceptable salt thereof, and any combination thereof. 
     
     
         5 . The coated pharmaceutical composition of  claim 1 , wherein the substituted cellulose acetate is water-swellable. 
     
     
         6 . The coated pharmaceutical composition of  claim 1 , wherein the degree of substitution of polar substituent is about 0.005 to about 2.6. 
     
     
         7 . The coated pharmaceutical composition of  claim 1 , wherein the degree of substitution of polar substituent is about 1 to about 2. 
     
     
         8 . The coated pharmaceutical composition of  claim 1 , wherein the polar substituent is a sulfate. 
     
     
         9 . The coated pharmaceutical composition of  claim 1 , wherein the polar substituent is a phosphate. 
     
     
         10 . The coated pharmaceutical composition of  claim 1 , wherein the polar substituent is a borate. 
     
     
         11 . The coated pharmaceutical composition of  claim 1 , wherein the substituted cellulose acetate has a degree of substitution of acetate of about 0.05 to about 3. 
     
     
         12 . A coated pharmaceutical composition comprising:
 a pharmaceutical composition having a coating that comprises a substituted cellulose acetate comprising a polar substituent that comprises an oxygen atom covalently bonded to a nonmetal selected from the group consisting of: sulfur, phosphorus, boron, and chlorine; wherein the substituted cellulose acetate has a degree of substitution of the polar substituent of about 0.005 to about 3.   
     
     
         13 . The coated pharmaceutical composition of  claim 12 , wherein the degree of substitution of polar substituent is about 1 to about 2. 
     
     
         14 . The coated pharmaceutical composition of  claim 12 , wherein the substituted cellulose acetate is water-swellable. 
     
     
         15 . The coated pharmaceutical composition of  claim 12 , wherein the polar substituent is a sulfate. 
     
     
         16 . A method comprising:
 coating a pharmaceutical composition with a coating comprising a substituted cellulose acetate comprising a polar substituent that comprises an oxygen atom covalently bonded to a nonmetal selected from the group consisting of: sulfur, phosphorus, boron, and chlorine; wherein the nonmetal is present in at least about 0.01% by weight of the substituted cellulose acetate.   
     
     
         17 . The method of  claim 16 , wherein the degree of substitution for an acetate substituent is about 0.05 to about 3. 
     
     
         18 . The method of  claim 16 , wherein the coating further comprises an additive selected from the group consisting of: a plasticizer, an annealing agent, an emulsifying agent, an emulsion stabilizer, and any combination of these. 
     
     
         19 . The method of  claim 16 , wherein the annealing agent comprises a water-soluble polymer selected from the group consisting of: a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a methyl cellulose, a methyl ethyl cellulose, a polyvinylpyrrolidone, a sodium carboxymethylcellulose, and any combination thereof. 
     
     
         20 . The method of  claim 16 , wherein the plasticizer comprises a plasticizer selected from the group consisting of: propylene glycol, glycerin, glycerin ester, glyceryl triacetate, polyethylene glycol, any derivative thereof, and any combination of these.