Preparation for improving the action of receptors

Abstract

The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation is advantageously applied in patients suffering from Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, depression, sleep disorders, impaired memory function, psychoses, dementia and ADHD.

1 - 23 . (canceled) 
     
     
         24 . A method for treating or reducing the severity of ADHD in a subject in need thereof, comprising administering to said subject a composition comprising:
 i) one or more polyunsaturated fatty acids; and   ii) magnesium and zinc.   
     
     
         25 . The method according to  claim 24 , wherein said polyunsaturated fatty acids comprise at least one ω-3 polyunsaturated fatty acid. 
     
     
         26 . The method according to  claim 25 , comprising at least docosahexaenoic acid (DHA). 
     
     
         27 . The method according to  claim 24 , wherein said polyunsaturated fatty acids comprise ω-3 polyunsaturated fatty acids and ω-6 polyunsaturated fatty acids, wherein the ratio between ω-6 fatty acids and ω-3 fatty acids is less than 2. 
     
     
         28 . The method according to  claim 24 , wherein the daily dose of ω-3 polyunsaturated fatty acids is at least 120 mg. 
     
     
         29 . The method according to  claim 28 , wherein the daily dose of ω-3 polyunsaturated fatty acids is at least 350 mg. 
     
     
         30 . The method according to  claim 24 , wherein more than 50% of the total fat in the composition is unsaturated fatty acids. 
     
     
         31 . The method according to  claim 24 , wherein the composition further comprises at least one of a form of vitamin B12, vitamin B6, pyridoxine, pyridoxamine, pyridoxal and folic acid. 
     
     
         32 . The method according to  claim 31 , wherein the composition comprises a combination of folic acid, a form of vitamin B6 and a form of vitamin B12. 
     
     
         33 . The method according to  claim 31 , wherein the composition comprises at least 250 μg folic acid per daily dose. 
     
     
         34 . The method according to,  claim 24 , wherein the composition further comprises nucleotides. 
     
     
         35 . The method according to  claim 24 , wherein the composition further comprises uridine, cytidine and/or the phosphates thereof. 
     
     
         36 . The method according to  claim 35 , wherein the composition comprises uridine monophosphate (UMP). 
     
     
         37 . The method according to  claim 24 , wherein the composition further comprises, per daily dose, at least 50 mg of uridine, cytidine, and/or the phosphates thereof. 
     
     
         38 . The method according to  claim 24 , wherein the composition further comprises phospholipids. 
     
     
         39 . The method according to  claim 38 , wherein the composition comprises a mixture of two or more phospholipids selected from the group consisting of phosphatidylserine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine. 
     
     
         40 . The method according to  claim 24 , wherein the composition further comprises one or more substances selected from thiamine, pantothenic acid, carnitine, vitamin C, vitamin E, carotenoids, coenzyme Q10 and flavinoids. 
     
     
         41 . The method according to  claim 24 , wherein the composition further comprises choline. 
     
     
         42 . The method according to  claim 41 , wherein the composition comprises at least 0.4 g choline equivalents per daily dose. 
     
     
         43 . The method according to  claim 24 , wherein the composition further comprises L-tryptophan, L-phenylalanine and L-tyrosine, or functional equivalents thereof, selected from the group of N-alkylated forms, esterified forms, salts, hydrolysed proteins, enriched proteins such as obtained by dialysis and membrane filtration techniques and α-lactalbumin. 
     
     
         44 . The method according to  claim 43 , wherein the composition comprises at least 0.5 g phenylalanine per/day and/or at least 130 mg tryptophan per/day. 
     
     
         45 . A preparation comprising:
 i) one or more polyunsaturated fatty acids; and   ii) one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium.