Methods of reducing salmonella in poultry

Abstract

Described herein are methods of reducing Salmonella in the intestines of poultry in need thereof by administering to a poultry bird an effective amount of an interleukin-10 peptide or an isolated antibody that specifically binds an interleukin-10 peptide. Administering may be performed within 1 to 4 weeks of harvest of the poultry in order to reduce Salmonella transmission to human consumers. Also included herein are finishing feeds that include an interleukin-10 peptide or an isolated antibody that specifically binds an interleukin-10 peptide.

1 . A method of reducing  Salmonella  in the intestines of poultry in need thereof, comprising
 administering to a poultry bird an effective amount of an interleukin-10 peptide or an isolated antibody that specifically binds an interleukin-10 peptide, wherein administering is within 1 to 4 weeks of harvest of the poultry.   
     
     
         2 . The method of  claim 1 , wherein the poultry bird is a  Salmonella  incubatory or convalescent carrier. 
     
     
         3 . The method of  claim 1 , wherein the interleukin-10 peptide is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, or a combination thereof. 
     
     
         4 . The method of  claim 1 , wherein the interleukin-10 peptide is SEQ ID NO: 2 or SEQ ID NO: 3. 
     
     
         5 . The method of  claim 1 , wherein the isolated antibody specifically binds SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 5. 
     
     
         6 . The method of  claim 1 , wherein the isolated antibody specifically binds SEQ ID NO: 2, or SEQ ID NO: 3. 
     
     
         7 . The method of  claim 1 , wherein the poultry is a chicken, a turkey, a duck, a quail, or a pheasant. 
     
     
         8 . The method of  claim 1 , wherein the poultry is a chicken, and wherein the interleukin-10 peptide or isolated antibody that specifically binds the interleukin-10 peptide is administered at weeks 3, 4, 5, 6, 7, and/or 8 after hatch. 
     
     
         9 . The method of  claim 1 , wherein the poultry is a turkey, and wherein the interleukin-10 peptide or isolated antibody that specifically binds the interleukin-10 peptide is administered at weeks 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 and/or 22 after hatch. 
     
     
         10 . The method of  claim 1 , wherein the peptide or isolated antibody is administered by injection or oral administration. 
     
     
         11 . The method of  claim 1 , comprising administering an isolated antibody, wherein the isolated antibody is in the form of an avian egg yolk antibody. 
     
     
         12 . The method of  claim 11 , wherein the isolated antibody specifically binds SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 5. 
     
     
         13 . The method of  claim 11 , wherein the isolated antibody specifically binds SEQ ID NO: 2, or SEQ ID NO: 3. 
     
     
         14 . The method of  claim 1 , wherein the peptide or isolated antibody is administered in the form of a poultry feed composition. 
     
     
         15 . The method of  claim 14 , wherein the poultry feed composition is a finishing feed comprising no added antibiotics. 
     
     
         16 . The method of  claim 14 , wherein the peptide or isolated antibody is present in the poultry feed composition in an amount of 0.15 mg/kg of animal feed to 100 mg/kg of poultry feed. 
     
     
         17 . A poultry finishing feed composition comprising a basal poultry finishing feed composition, an amount of an interleukin-10 peptide or an isolated antibody that specifically binds an interleukin-10 peptide, and no added antibiotics, wherein the basal poultry finishing feed composition is suitable for feeding during the final 1 to 4 weeks prior to slaughter. 
     
     
         18 . The poultry feed finishing composition of  claim 17 , wherein the isolated antibody is in the form of an egg yolk antibody. 
     
     
         19 . The poultry feed finishing composition of  claim 18 , wherein the isolated antibody specifically binds SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 5. 
     
     
         20 . The poultry feed finishing composition of  claim 18 , wherein the isolated antibody specifically binds SEQ ID NO: 2, or SEQ ID NO: 3. 
     
     
         21 . The poultry feed finishing composition of  claim 17 , wherein an interleukin-10 peptide is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, or a combination thereof. 
     
     
         22 . The poultry feed finishing composition of  claim 17 , wherein an interleukin-10 peptide is SEQ ID NO: 2, SEQ ID NO: 3, or a combination thereof.