Bone repair material

Abstract

Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.

1 . A sliceable bone repair material comprising a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules, and wherein said scaffold is made of a synthetic ceramic material and comprises interconnected macropores having a diameter above 100 μm, said scaffold having a total porosity of 80 to 95%, and the total volume of the hydrogel is smaller than the total volume of the interconnected macropores. 
     
     
         2 . Bone repair material according to  claim 1 , wherein the hydrogel is a reconstituted hydrogel of a xerogel. 
     
     
         3 . Bone repair material according to  claim 1 , wherein the hydrogel has a water content of more than 90% by weight. 
     
     
         4 . Bone repair material according to  claim 1 , wherein 30 to 60 of the total volume of the interconnected macropores is filled with said hydrogel. 
     
     
         5 . Bone repair material according to  claim 1 , wherein the hydrogel has a pH from 8.0 to 9.5. 
     
     
         6 . Bone repair material according to  claim 1 , wherein the first precursor molecule has a core with 2 to 4 polyethylene glycol chains, each chain having a terminal acrylate group. 
     
     
         7 . Bone repair material according to  claim 1 , wherein the second precursor molecule has a core with 2 to 4 polyethylene glycol chains, each chain having a thiol group which is terminal or attached to the second to last carbon atom. 
     
     
         8 . Bone repair material according to  claim 1  further comprising a bioactive agent. 
     
     
         9 . Bone repair material according to  claim 8 , wherein the bioactive agent is selected from the group of RGD and BMP. 
     
     
         10 . A sliceable bone repair material comprising a porous block-shaped scaffold containing a xerogel, wherein the xerogel is formed by Michael type addition of at least two precursor molecules, and wherein said scaffold is made of a synthetic ceramic material and comprises interconnected macropores having a diameter above 100 μm, said scaffold having a total porosity of 80 to 95%, and the total volume of the xerogel is smaller than the total volume of the interconnected macropores. 
     
     
         11 . Bone repair material according to  claim 10 , wherein the first precursor molecule has a core with 2 to 4 polyethylene glycol chains, each chain having a terminal acrylate group. 
     
     
         12 . Bone repair material according to  claim 10 , wherein the second precursor molecule has a core with 2 to 4 polyethylene glycol chains, each chain having a thiol group which is terminal or attached to the second to last carbon atom. 
     
     
         13 . Kit comprising a bone repair material according to  claim 10  and a buffered solution, said buffered solution being stored in a separate container. 
     
     
         14 . Kit according to  claim 13 , where in the buffered solution is between pH 8.0 and 9.5. 
     
     
         15 . Kit according to  claim 14 , wherein the buffered solution is between pH 8.6 and 9.5. 
     
     
         16 . Bone repair material according to  claim 5 , wherein the hydrogel has a pH from 8.6 to 9.5.