Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and Methods for Use in Urological Procedures

Abstract

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 
     
         1 . A stable composition for us in inhibiting pain/inflammation and spasm, comprising a combination of ketoprofen, nifedipine, propyl gallate and sodium metabisulfite in a liquid carrier, wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of between 10:1 to 1:10. 
     
     
         2 . The composition of  claim 1 , wherein the liquid carrier comprises an aqueous solvent. 
     
     
         3 . The composition of  claim 2 , wherein the composition further comprises polyethylene glycol 400 as a cosolvent. 
     
     
         4 . The composition of  claim 1 , wherein the composition further comprises a citric acid buffer. 
     
     
         5 . The composition of  claim 1 , wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of between 5:1 to 1:5. 
     
     
         6 . The composition of  claim 5 , wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of between 4:1 to 1:1. 
     
     
         7 . The composition of  claim 6 , wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of 3:1 plus or minus 20%.