Use of lipid conjugates in the treatment of diseases

Abstract

This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a polymer; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.

What we claim is: 
     
         1 . A compound represented by the structure of the general formula (A): 
       
         
           
           
               
               
           
         
         wherein 
         L is a lipid; 
         Z is either nothing, ethanolamine, serine, phosphate, inositol, choline or glycerol; 
         Y is either nothing or a spacer group ranging in length from 2 to 30 atoms; 
         X is a polymer other than glycosominoglycan; and 
         n is a number from 1 to 1000; 
         wherein said L-Z forms phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylcholine or phosphatidylglycerol. 
       
     
     
         2 . The compound of  claim 1 , wherein said lipid comprises a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 carbon atoms. 
     
     
         3 . The compound of  claim 2 , wherein said alkyl chain comprises a palmitic acid moiety or a myristic acid moiety. 
     
     
         4 . The compound of  claim 1 , wherein X is a polysaccharide. 
     
     
         5 . The compound of  claim 4 , wherein said polysaccharide is alginate. 
     
     
         6 . The compound of  claim 1 , wherein Y is nothing. 
     
     
         7 . The compound of  claim 1 , wherein any bond between L, Z, Y and X is either an amide or an esteric bond. 
     
     
         8 . The compound of  claim 1 , wherein n is a number greater than 1. 
     
     
         9 . The compound of  claim 1 , wherein n is a number from 1 to 500. 
     
     
         10 . The compound of  claim 1 , wherein n is a number from 1 to 100.