US2015025224A1PendingUtilityA1

Antagonists of neuropilin receptor function and use thereof

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Assignee: CHILDRENS MEDICAL CENTERPriority: Dec 9, 1997Filed: Oct 1, 2014Published: Jan 22, 2015
Est. expiryDec 9, 2017(expired)· nominal 20-yr term from priority
Inventors:Michael KlagsbrunShay SokerHarry H. MiaoSeiji Takashima
C07K 16/2863A61K 39/39558A61K 48/00A61P 35/04C07K 16/28C07K 14/71A61K 38/00
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Claims

Abstract

The present invention relates to antagonists of neuropilin receptor function and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A neuropilin antagonist that binds neuropilin and has VEGF antagonist activity as determined by the human umbilical vein endothelial cell (HUVEC) proliferation assay using VEGF165.

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