Compounds, Methods, and Treatments for Abnormal Signaling Pathways for Prenatal and Postnatal Development

Abstract

The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.

1 . A compound effective for moderating the activity of PKM2 via signaling cascades, to regulate metabolic pathways in rapidly growing tissues related to disease states such as cancer, obesity, and diabetes including any D-Chiro inositol as listed herein, their isomeric analogous phosphate derivatives, and/or their isomeric analogous phosphatidyl inositol phosphate derivatives comprising:
 at least one compound selected from the group consisting of   D-chiro-inositol 1,2,3,4-tetraphosphate,   D-chiro-inositol 1,2,3,5-tetraphosphate,   D-chiro-inositol 1,2,3,6-tetraphosphate,   D-chiro-inositol 1,2,4,5-tetraphosphate,   D-chiro-inositol 1,2,4,6-tetraphosphate,   D-chiro-inositol 1,2,5,6-tetraphosphate,   D-chiro-inositol 1,3,4,5-tetraphosphate,   D-chiro-inositol 1,3,4,6-tetraphosphate,   D-chiro-inositol 1,3,5,6-tetraphosphate,   D-chiro-inositol 1,4,5,6-tetraphosphate,   D-chiro-inositol 2,3,4,5-tetraphosphate,   D-chiro-inositol 2,3,4,6-tetraphosphate,   D-chiro-inositol 2,3,5,6-tetraphosphate,   D-chiro-inositol 2,4,5,6-tetraphosphate,   D-chiro-inositol 3,4,5,6-tetraphosphate,   D-chiro-inositol 1,2,3,4,5-pentaphosphate,   D-chiro-inositol 1,2,3,4,6-pentaphosphate,   D-chiro-inositol 1,2,3,5,6-pentaphosphate,   D-chiro-inositol 1,2,4,5,6-pentaphosphate,   D-chiro-inositol 1,3,4,5,6-pentaphosphate,   D-chiro-inositol 2,3,4,5,6-pentaphosphate,   D-chiro-inositol 1,2,3,4,5,6-hexaphosphate,   D-chiro-inositol 1,2,3,4,5-pentaphosphate-6-pyrophosphate,   D-chiro-inositol 1,2,3,4,6-pentaphosphate-5-pyrophosphate,   D-chiro-inositol 1,2,3,5,6-pentaphosphate-4-pyrophosphate,   D-chiro-inositol 1,2,4,5,6-pentaphosphate-3-pyrophosphate,   D-chiro-inositol 1,3,4,5,6-pentaphosphate-2-pyrophosphate,   D-chiro-inositol 2,3,4,5,6-pentaphosphate-1-pyrophosphate,   D-chiro-inositol 1,2,3-triphosphate-4,5-dipyrophosphate,   D-chiro-inositol 1,2,3-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,2,3-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 1,2,4-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 1,2,4-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 1,2,4-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 1,2,5-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 1,2,5-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 1,2,5-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,2,6-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 1,2,6-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 1,2,6-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,3,4-triphosphate-2,5-di pyrophosphate,   D-chiro-inositol 1,3,4-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 1,3,4-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 1,3,5-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 1,3,5-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 1,3,5-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,3,6-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 1,3,6-triphosphate-2,5-dipyrophosphate,   D-chiro-inositol 1,3,6-triphosphate-4,5-dipyrophosphate,   D-chiro-inositol 1,4,5-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1,4,5-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 1,4,5-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 1,4,6-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1,4,6-triphosphate-2,5-dipyrophosphate,   D-chiro-inositol 1,4,6-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 1,5,6-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1,5,6-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 1,5,6-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 2,3,4-triphosphate-1,5-dipyrophosphate,   D-chiro-inositol 2,3,4-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 2,3,4-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 2,3,5-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 2,3,5-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 2,3,5-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 2,3,6-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 2,3,6-triphosphate-1,5-dipyrophosphate,   D-chiro-inositol 2,3,6-triphosphate-4,5-dipyrophosphate,   D-chiro-inositol 2,4,5-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 2,4,5-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 2,4,5-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 2,4,6-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 2,4,6-triphosphate-1,5-dipyrophosphate,   D-chiro-inositol 2,4,6-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 2,5,6-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 2,5,6-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 2,5,6-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 3,4,5-triphosphate-1,2-dipyrophosphate,   D-chiro-inositol 3,4,5-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 3,4,5-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 3,5,6-triphosphate-1,2-dipyrophosphate,   D-chiro-inositol 3,5,6-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 3,5,6-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 4,5,6-triphosphate-1,2-dipyrophosphate,   D-chiro-inositol 4,5,6-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 4,5,6-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1-phosphate-2,3,4-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,3,5-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,3,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,4,5-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,4,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,5,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-3,4,5-tripyrophosphate,   D-chiro-inositol 1-phosphate-3,4,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-3,5,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-4,5,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,3,4-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,3,5-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,3,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,4,5-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,4,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,5,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-3,4,5-tripyrophosphate,   D-chiro-inositol 2-phosphate-3,4,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-3,5,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-4,5,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,2,4-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,2,5-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,2,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,4,5-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,4,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,5,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-3,4,5-tripyrophosphate,   D-chiro-inositol 3-phosphate-3,4,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-3,5,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-4,5,6-tripyrophosphate,   D-1-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-6-O-methyl-Dchiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   1D-6-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, and   1D-1-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate.   
     
     
         2 . A process for moderating the activity of PKM2 via signaling cascades, to regulate metabolic pathways in rapidly growing tissues associated with conditions such as cancer, obesity, and diabetes including any D-Chiro inositol as listed herein, their isomeric analogous phosphate derivatives, and/or their isomeric analogous phosphatidyl inositol phosphate derivatives comprising:
 administering to a patient in need thereof, an effective amount of one or more compounds selected from the group consisting of   D-chiro-inositol 1,2,3,4-tetraphosphate,   D-chiro-inositol 1,2,3,5-tetraphosphate,   D-chiro-inositol 1,2,3,6-tetraphosphate,   D-chiro-inositol 1,2,4,5-tetraphosphate,   D-chiro-inositol 1,2,4,6-tetraphosphate,   D-chiro-inositol 1,2,5,6-tetraphosphate,   D-chiro-inositol 1,3,4,5-tetraphosphate,   D-chiro-inositol 1,3,4,6-tetraphosphate,   D-chiro-inositol 1,3,5,6-tetraphosphate,   D-chiro-inositol 1,4,5,6-tetraphosphate,   D-chiro-inositol 2,3,4,5-tetraphosphate,   D-chiro-inositol 2,3,4,6-tetraphosphate,   D-chiro-inositol 2,3,5,6-tetraphosphate,   D-chiro-inositol 2,4,5,6-tetraphosphate,   D-chiro-inositol 3,4,5,6-tetraphosphate,   D-chiro-inositol 1,2,3,4,5-pentaphosphate,   D-chiro-inositol 1,2,3,4,6-pentaphosphate,   D-chiro-inositol 1,2,3,5,6-pentaphosphate,   D-chiro-inositol 1,2,4,5,6-pentaphosphate,   D-chiro-inositol 1,3,4,5,6-pentaphosphate,   D-chiro-inositol2,3,4,5,6-pentaphosphate,   D-chiro-inositol 1,2,3,4,5,6-hexaphosphate,   D-chiro-inositol 1,2,3,4,5-pentaphosphate-6-pyrophosphate,   D-chiro-inositol 1,2,3,4,6-pentaphosphate-5-pyrophosphate,   D-chiro-inositol 1,2,3,5,6-pentaphosphate-4-pyrophosphate,   D-chiro-inositol 1,2,4,5,6-pentaphosphate-3-pyrophosphate,   D-chiro-inositol 1,3,4,5,6-pentaphosphate-2-pyrophosphate,   D-chiro-inositol 2,3,4,5,6-pentaphosphate-1-pyrophosphate,   D-chiro-inositol 1,2,3-triphosphate-4,5-dipyrophosphate,   D-chiro-inositol 1,2,3-tri phosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,2,3-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 1,2,4-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 1,2,4-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 1,2,4-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 1,2,5-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 1,2,5-triphosphate-3,6-di pyrophosphate,   D-chiro-inositol 1,2,5-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,2,6-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 1,2,6-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 1,2,6-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,3,4-triphosphate-2,5-dipyrophosphate,   D-chiro-inositol 1,3,4-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 1,3,4-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 1,3,5-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 1,3,5-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 1,3,5-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 1,3,6-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 1,3,6-triphosphate-2,5-dipyrophosphate,   D-chiro-inositol 1,3,6-triphosphate-4,5-dipyrophosphate,   D-chiro-inositol 1,4,5-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1,4,5-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 1,4,5-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 1,4,6-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1,4,6-triphosphate-2,5-dipyrophosphate,   D-chiro-inositol 1,4,6-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 1,5,6-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1,5,6-triphosphate-2,4-di pyrophosphate,   D-chiro-inositol 1,5,6-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 2,3,4-triphosphate-1,5-dipyrophosphate,   D-chiro-inositol 2,3,4-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 2,3,4-triphosphate-5,6-dipyrophosphate,   D-chiro-inositol 2,3,5-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 2,3,5-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 2,3,5-triphosphate-4,6-dipyrophosphate,   D-chiro-inositol 2,3,6-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 2,3,6-tri phosphate-1,5-dipyrophosphate,   D-chiro-inositol 2,3,6-triphosphate-4,5-dipyrophosphate,   D-chiro-inositol 2,4,5-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 2,4,5-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 2,4,5-triphosphate-3,6-dipyrophosphate,   D-chiro-inositol 2,4,6-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 2,4,6-triphosphate-1,5-dipyrophosphate,   D-chiro-inositol 2,4,6-triphosphate-3,5-dipyrophosphate,   D-chiro-inositol 2,5,6-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 2,5,6-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 2,5,6-triphosphate-3,4-dipyrophosphate,   D-chiro-inositol 3,4,5-triphosphate-1,2-dipyrophosphate,   D-chiro-inositol 3,4,5-triphosphate-1,6-dipyrophosphate,   D-chiro-inositol 3,4,5-triphosphate-2,6-dipyrophosphate,   D-chiro-inositol 3,5,6-triphosphate-1,2-dipyrophosphate,   D-chiro-inositol 3,5,6-triphosphate-1,4-dipyrophosphate,   D-chiro-inositol 3,5,6-triphosphate-2,4-dipyrophosphate,   D-chiro-inositol 4,5,6-triphosphate-1,2-dipyrophosphate,   D-chiro-inositol 4,5,6-triphosphate-1,3-dipyrophosphate,   D-chiro-inositol 4,5,6-triphosphate-2,3-dipyrophosphate,   D-chiro-inositol 1-phosphate-2,3,4-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,3,5-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,3,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,4,5-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,4,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-2,5,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-3,4,5-tripyrophosphate,   D-chiro-inositol 1-phosphate-3,4,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-3,5,6-tripyrophosphate,   D-chiro-inositol 1-phosphate-4,5,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,3,4-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,3,5-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,3,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,4,5-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,4,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-1,5,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-3,4,5-tripyrophosphate,   D-chiro-inositol 2-phosphate-3,4,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-3,5,6-tripyrophosphate,   D-chiro-inositol 2-phosphate-4,5,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,2,4-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,2,5-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,2,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,4,5-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,4,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-1,5,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-3,4,5-tripyrophosphate,   D-chiro-inositol 3-phosphate-3,4,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-3,5,6-tripyrophosphate,   D-chiro-inositol 3-phosphate-4,5,6-tripyrophosphate,   D-1-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-1-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-2-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogenphosphate],   D-3-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-3-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogenphosphate],   D-4-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-4-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogenphosphate],   D-5-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-5-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   D-6-deoxy-5-0-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate],   1D-6-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-6-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-61-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-5-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxylmethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-4-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D3-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-3-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-2-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate,   1D-1-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, and   1D1-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate;   whereby said patient's disease state is effectively moderated so as to alleviate the diagnosed condition.