US2015011502A1PendingUtilityA1

Methods and compositions to treat myocardial conditions

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Assignee: ABBOTT CARDIOVASCULAR SYSTEMSPriority: Apr 15, 2003Filed: Sep 19, 2014Published: Jan 8, 2015
Est. expiryApr 15, 2023(expired)· nominal 20-yr term from priority
Inventors:John StankusEugene T. Michal
A61P 43/00A61P 9/14A61P 9/10A61P 7/04A61P 7/02A61P 9/04A61K 31/79A61K 31/00A61K 45/06A61K 38/1858A61L 27/50A61K 38/1866A61K 36/886A61K 49/0404A61K 31/78A61L 24/043A61L 2430/20A61L 27/20A61K 47/34A61N 1/36521A61L 27/54A61K 47/62A61K 41/0042A61K 38/1841A61K 38/1825A61K 31/734A61N 1/3625A61K 31/728A61K 38/1891A61K 38/40A61K 47/60A61K 9/0024A61K 35/34A61K 38/18A61K 31/732A61K 47/02
66
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Claims

Abstract

Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structural reinforcing agents such as those agents containing aloe-derived pectin. In other embodiments, the structural reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method comprising:
 identifying an infarct region of a ventricle;   introducing a first component comprising an alginate and a second component comprising calcium to a site of the infarct region, wherein the first component and the second component contact each other at the site; and   introducing one of a viscosifier or a tissue adhesive component to the site.   
     
     
         2 . The method of  claim 1 , wherein the site comprises a plurality of sites. 
     
     
         3 . The method of  claim 1 , wherein the viscosifier comprises a type 1 gel. 
     
     
         4 . The method of  claim 1 , wherein the tissue adhesive component comprises one of laminin-5, polyacrylic acid or chitosan. 
     
     
         5 . The method of  claim 1 , further comprising administering an aloe-derived pectin composition to the site. 
     
     
         6 . The method of  claim 5 , wherein the aloe-derived pectin composition comprises a growth factor or cytokine. 
     
     
         7 . The method of  claim 5 , wherein the aloe-derived pectin composition comprises cells. 
     
     
         8 . The method of  claim 5 , wherein the aloe-derived pectin composition comprises a natural or synthetic gel. 
     
     
         7 . The method of  claim 1 , wherein the introducing occurs with two weeks of a myocardial infarction. 
     
     
         8 . The method of  claim 1 , wherein the introducing occurs with five weeks of a myocardial infarction.

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