Low viscosity highly concentrated suspensions

Abstract

The present invent ion also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.

1 .- 50 . (canceled) 
     
     
         51 . A method of delivering a suspension of protein particles to a subject, the method comprising subcutaneously injecting said suspension into said subject, wherein the protein concentration within said suspension is greater than 200 mg/mL and the viscosity of said suspension is less than 50 centipoise. 
     
     
         52 . The method of  claim 51 , wherein said injection is accomplished using a syringe comprising a 21-gauge to 27-gauge needle. 
     
     
         53 . The method of  claim 52 , wherein said syringe comprises a 25-gauge to 27-gauge needle. 
     
     
         54 . The method of  claim 51 , wherein said suspension has a volume of 5 mL or less. 
     
     
         55 . The method of  claim 51 , wherein said suspension has a volume of 1.5 mL or less. 
     
     
         56 . The method of  claim 51 , wherein said particles are sub-micron sized particles.