Biomedical device, method for manufacturing the same and use thereof

Abstract

A three-dimensional biomedical device having an osteoinductive first area with a controlled porosity and a second area, which is produced by laser technology from a powder including one of ceramics, metals, metal alloys, bioactive glasses, lead zirconate titanate and biocompatible polymers, or mixtures thereof. The ratio of the porosities from the second area to the first area is equal or less than one, preferably from 0.001 to 0.9. A method for manufacturing the device for fitting in a bone defect, wherein a virtual object is designed with a computer-aid designed software, and the device is manufactured by laser technology including layering a powder onto a plate ( 7 ) so that a layer of a predetermined thickness is formed; the laser beam ( 8 ) selectively processes the powder to produce a processed layer, and, thus, layer after layer, the layers are joined together until the biomedical device is formed.

1 . A three-dimensional biomedical device, having an osteoconductive first area with a controlled porosity and a second area, the device being produced by a laser technology from a powder comprising a material selected from the group consisting of ceramics, metals, metal alloys, bioactive glasses, lead zirconatetitanate, biocompatible polymers, and mixtures thereof, the ratio of the porosity of the second area to the porosity of the first area being equal or less than one. 
     
     
         2 . The biomedical device according to  claim 1 , wherein the powder comprises or consists of ceramics selected from the group consisting of alumina or alumina derivative, ceramic phosphates, apatite derivatives, zirconia, zirconia derivatives, zirconia-toughened alumina (ZTA), alumina-toughened-zirconia (ATZ), alumina-zircona, ytria-zirconia (TZP), and wallostonite. 
     
     
         3 . The biomedical device according to  claim 1 , wherein the powder comprises or consists of a mixture hydroxyapatite/tricalcium phosphate in a ratio ranging from 55/45 to 90/10. 
     
     
         4 . The biomedical device according to  claim 1 , wherein said bioactive glasses are silicate type materials comprising SiO 2 , CaO and optionally Na 2 O, and/or P 2 O 5 . 
     
     
         5 . The biomedical device according to  claim 1 , wherein the pores of the first area have a diameter from 10 to 1000 micrometers. 
     
     
         6 . The biomedical device according to  claim 1 , wherein the porosity of the first area ranges from 20 to 90 vol %. 
     
     
         7 . The biomedical device according to  claim 1 , wherein the first area, prior to implantation, is seeded or colonized by tissue forming cells immunologically compatible with the eventual implant recipient. 
     
     
         8 . The biomedical device according to  claim 1 , wherein the first area, prior to implantation, is impregnated with a cell growth medium and/or growth factors suitable for osteoblasts growth. 
     
     
         9 . The biomedical device according to  claim 1 , which is implantable. 
     
     
         10 . The biomedical device according to  claim 1 , further comprising a sensor.