Nanoparticle loaded electrospun implants or coatings for drug release

Abstract

Medical devices, such as stents, including a fibrous layer including particles are disclosed. Methods of forming such medical devices using electrospinning are disclosed.

1 . (canceled) 
     
     
         2 . A stent comprising:
 a stent scaffolding composed of a pattern including a plurality of interconnecting fibrous struts, wherein the fibrous struts are composed of a network of polymer fibers, wherein the fibers have a thickness of 250 to 500 nm, wherein the fibrous struts include particles that are encapsulated within the fibers, partially encapsulated within the fibers, and entrapped between the fibers of the fibrous struts, wherein the particles, fibers, or both comprise an active agent.   
     
     
         3 . The stent of  claim 2 , wherein the polymer fibers are formed from a hydrogel, shape memory polymer, bioabsorbable polymer, biostable polymer, or a combination thereof 
     
     
         4 . The stent of  claim 2 , wherein the particles are formed from biostable polymer; a bioabsorbable polymer; a biosoluble material; a biopolymer; a biostable metal; a bioerodible metal; a block copolymer of a bioabsorbable polymer or a biopolymer; a ceramic material; a bioabsorbable glass; salts; fullerenes; lipids; and carbon nanotubes. 
     
     
         5 . The stent of  claim 2 , wherein the fibrous network exhibits shape memory properties. 
     
     
         6 . The stent of  claim 2 , wherein an average pore size of the fibrous struts is 250 nm-20 μm. 
     
     
         7 . The stent of  claim 2 , wherein a void fraction of the fibrous struts is 20-85%. 
     
     
         8 . The stent of  claim 2 , wherein a concentration of particles in the struts is 0.5-50 vol %. 
     
     
         9 . The stent of  claim 2 , wherein the fibers are composed of poly(L-lactide). 
     
     
         10 . The stent of  claim 2 , wherein the stent scaffolding is fabricated from a tube composed of the network of polymer fibers by laser cutting the pattern in the tube.