Natriuretic polypeptide delivery systems

Abstract

This document provides natriuretic polypeptide delivery systems. For example, methods and materials related to natriuretic polypeptide delivery systems, methods and materials related to the use of such delivery systems to deliver natriuretic polypeptides to a mammal over a pro-longed period of time (e.g., weeks to months), and methods and materials related to treating heart failure conditions are provided.

1 - 12 . (canceled) 
     
     
         13 . A method for treating a mammal to increase plasma natriuretic polypeptide levels and plasma cGMP levels in said mammal, wherein said method comprises administering a polymer gel composition to said mammal, wherein said polymer gel composition comprises a natriuretic polypeptide, poly(lactic-co-glycolic acid), N-methyl-2-pyrrolidinone, and triacetin, wherein the poly(lactic-co-glycolic acid) of said composition has an intrinsic viscosity between 0.3 and 3 dL/g, and wherein said natriuretic polypeptide is released from said polymer gel composition into the circulation of said mammal over a period of time greater than 2 weeks following administration of said polymer gel composition to said mammal. 
     
     
         14 . The method of  claim 13 , wherein mammal is a human. 
     
     
         15 . The method of  claim 13 , wherein said natriuretic polypeptide is CD-NP. 
     
     
         16 . The method of  claim 13 , wherein said natriuretic polypeptide comprises the amino acid sequence set forth in one of SEQ ID NOs:1-10. 
     
     
         17 . The method of  claim 13 , wherein said polymer gel composition comprises from about 0.1 percent and 0.5 percent of said natriuretic polypeptide by weight. 
     
     
         18 . The method of  claim 13 , wherein said polymer gel composition comprises from about 15 percent and 45 percent of said poly(lactic-co-glycolic acid) by weight. 
     
     
         19 . The method of  claim 13 , wherein said polymer gel composition comprises from about 15 percent and 25 percent of the poly(lactic-co-glycolic acid) by weight. 
     
     
         20 . The method of  claim 13 , wherein said polymer gel composition comprises from about 1 percent and 10 percent of triacetin by weight. 
     
     
         21 . The method of  claim 13 , wherein said polymer gel composition comprises acid capped poly(lactic-co-glycolic acid).