US2014350083A1PendingUtilityA1
Genetic Inhibition by Double-Stranded RNA
Assignee: CARNEGIE INST OF WASHINGTONPriority: Dec 23, 1997Filed: Aug 8, 2014Published: Nov 27, 2014
Est. expiryDec 23, 2017(expired)· nominal 20-yr term from priority
Inventors:Andrew FireStephen KostasMary MontgomeryLisa TimmonsSiqun XuHiroaki TabaraSamuel E. DriverCraig C. Mello
A61P 35/02C12N 2310/321A01K 2217/05A61K 31/713A61K 31/7105A61P 43/00A01K 2227/703C12N 15/113C12N 15/85C12N 2310/14C12N 15/8218C12N 2310/11C12N 2310/50C12N 2310/53C12N 15/8285A61P 35/00
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Claims
Abstract
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
Claims
exact text as granted — not AI-modified1 . A method to inhibit expression of a target gene in a cell comprising introduction of a ribonucleic acid (RNA) into the cell in an amount sufficient to inhibit expression of the target gene, wherein the RNA comprises a double-stranded structure with an identical nucleotide sequence as compared to a portion of the target gene.
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