Compounds and Method for Modulating Inflammatory Reactions

Abstract

The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation. Reduction of inflammation manifestations and reactions occurs by using an anti-S100 polynucleotide or polypeptide inhibitor or antagonist, which is essentially targeted against S100A8, S100A9 or S100A12, alone or in combination with other inhibitors of chemokines or immune modulating products.

What is claimed is: 
     
         1 . A method for the treatment of an inflammatory reaction selected from Crohn's disease and ulcerative colitis in a human suffering therefrom comprising administering to said human an inflammatory reaction treatment effective amount of an antibody or a fragment thereof directed against S100A9. 
     
     
         2 . The method of  claim 1 , wherein said inflammatory reaction is Crohn's disease. 
     
     
         3 . The method of  claim 1 , wherein said inflammatory reaction is ulcerative colitis. 
     
     
         4 . The method of  claim 1 , wherein said antibody or fragment thereof is a polyclonal or a monoclonal antibody. 
     
     
         5 . The method of  claim 1 , wherein said administration is performed by intravenous, oral, intranasal, subcutaneous, topical, or intraperitoneal administration.