US2014335536A1PendingUtilityA1

Vaccine for the treatment of mycobaterium related disorders

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Assignee: MARFL ABPriority: Dec 17, 2007Filed: May 28, 2014Published: Nov 13, 2014
Est. expiryDec 17, 2027(~1.4 yrs left)· nominal 20-yr term from priority
Inventors:Leif KirsebomSantanu DasguptaPontus LarssonJaydip Ghosh
G01N 33/5695A61K 39/04A61P 31/06A61P 37/04A61P 31/08A61P 31/04A61K 38/164
46
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Claims

Abstract

The invention relates to genes and proteins involved in the sporulation of Mycobacteria and the use thereof in the technical fields of immunology and medicine.

Claims

exact text as granted — not AI-modified
1 . A method for detecting spores derived from  Mycobacteria  in a sample comprising determining the presence in said sample of a peptide chosen from the group consisting of mycobacterial CotA, CotD, CotT, CotSA, SpoVK, SpoVE, Soj, SpoIIIE, YrbC and peptides having an amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 16, 18, 20, 22, 24, and 26, and immunogenic fragments thereof. 
     
     
         2 . The method according to  claim 1 , wherein the  Mycobacteria  is selected from  Mycobacterium marinum, Mycobacterium bovis, Mycobacterium tuberculosis , and  Mycobacterium avium  subspecies  paratuberculosis.    
     
     
         3 . The method according to  claim 1 , wherein the sample is a body fluid sample from a human or animal, a food product sample, a feed product sample, or an environmental sample. 
     
     
         4 . The method according to  claim 3 , wherein the sample is a body fluid sample selected from the group consisting of blood, serum, bronchoalveolar lavage fluid, saliva, urine, feces, and tears. 
     
     
         5 . The method according to  claim 3 , wherein the sample is a food product sample selected from the group consisting of milk, cheese, butter, vegetables, and meat. 
     
     
         6 . The method according to  claim 1 , wherein the detection is performed through an immunological assay. 
     
     
         7 . The method according to  claim 4 , wherein the immunological assay is an ELISA assay. 
     
     
         8 . The method according to  claim 2 , wherein the peptide is CotA. 
     
     
         9 . The method according to  claim 2 , wherein the peptide is CotD. 
     
     
         10 . The method according to  claim 2 , wherein the peptide is CotT. 
     
     
         11 . The method according to  claim 2 , wherein the peptide is CotSA. 
     
     
         12 . The method according to  claim 2 , wherein the peptide is SpoVK. 
     
     
         13 . The method according to  claim 2 , wherein the peptide is SpoVE. 
     
     
         14 . The method according to  claim 2 , wherein the peptide is Soj. 
     
     
         15 . The method according to  claim 2 , wherein the peptide is SpoIIIE. 
     
     
         16 . The method according to  claim 2 , wherein the peptide is YrbC. 
     
     
         17 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 2. 
     
     
         18 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 4. 
     
     
         19 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 6. 
     
     
         20 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 8. 
     
     
         21 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 10. 
     
     
         22 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 12. 
     
     
         23 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 16. 
     
     
         24 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 18. 
     
     
         25 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 20. 
     
     
         26 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 22. 
     
     
         27 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 24. 
     
     
         28 . The method according to  claim 2 , wherein the peptide has an amino acid sequence according to SEQ ID NO: 26.

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