US2014329311A1PendingUtilityA1

Induction of human embryonic stem cell derived cardiac pacemaker or chamber-type cardiomyocytes by manipulation of neuregulin signaling

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Assignee: UNIV WASHINGTONPriority: Nov 3, 2008Filed: Jul 22, 2014Published: Nov 6, 2014
Est. expiryNov 3, 2028(~2.3 yrs left)· nominal 20-yr term from priority
Inventors:Michael LaflammeWei Zhu
C12N 2501/155A61P 9/00C12N 2501/11C12N 2501/16A61K 35/12C12N 2510/00C12N 2501/13C12N 5/0657C12N 2502/13C12N 2533/90C12N 2501/115C12N 2506/02
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Claims

Abstract

The present invention is directed to methods of producing cardiomyocytes having a nodal/pacemaker phenotype and cardiomyocytes having an atrial/ventricular phenotype. Isolated populations of nodal/pacemaker and atrial/ventricular cardiomyocytes are also disclosed. Methods of treating a subject having cardiac arrhythmia and a subject in need of cardiac tissue repair using the isolated populations of nodal/pacemaker cardiomyocytes and atrial/ventricular cardiomyocytes, respectively, are also disclosed.

Claims

exact text as granted — not AI-modified
1 - 19 . (canceled) 
     
     
         20 . An isolated population of atrial/ventricular cardiomyocytes. 
     
     
         21 . The isolated population of atrial/ventricular cardiomyocytes of claim  38 , wherein the cardiomyocytes have an average spontaneous firing rate of 85 bpm and a rapid action potential upstroke of >15 V/s. 
     
     
         22 . The isolated population of atrial/ventricular cardiomyocytes of claim  38 , wherein the cardiomyocytes are characterized by a higher level of SCN5A and KCNJ2 expression and a lower level of HCN expression compared to non-atrial/ventricular cardiomyocytes. 
     
     
         23 . The isolated population of atrial/ventricular cardiomyocytes of claim  38 , wherein the cardiomyocytes are human cardiomyocytes.

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