US2014316144A1PendingUtilityA1

Antiviral compounds

63
Assignee: GILEAD SCIENCES INCPriority: May 16, 2012Filed: Jun 26, 2014Published: Oct 23, 2014
Est. expiryMay 16, 2032(~5.8 yrs left)· nominal 20-yr term from priority
Inventors:Elizabeth M. BaconJeromy J. CottellJohn O. LinkTeresa Alejandra Trejo Martin
A61P 31/14A61P 31/12A61P 31/00A61K 31/4188A61P 43/00C07D 491/052A61P 1/16A61K 31/7068C07D 491/04A61K 31/7072A61K 31/7056A61K 38/21A61K 45/06C07D 413/14
63
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Claims

Abstract

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Claims

exact text as granted — not AI-modified
1 . A compound of formula (I):
   E 1a -V 1a —C(═O)—P 1a —W 1a —P 1b —C(═O)—V 1b -E 1b   (I)
   
       wherein:
 W 1a  is 
 
       
         
           
           
               
               
           
         
       
       and W 1a  is substituted with substituted aryl;
 Y 5  is —O—C(═O)—; X 5  is —CH 2 —CH 2 —; 
 E 1a  is —N(H)(cycloalkyloxycarbonyl); 
 E 1b  is —N(H)(cycloalkyloxycarbonyl); 
 V 1a  and V 1b  are each independently selected from: 
 
       
         
           
           
               
               
           
         
         P 1a  and P 1b  are selected from:

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