US2014309398A1PendingUtilityA1

Oligomer-corticosteroid conjugates

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Assignee: NAKTAR THERAPEUTICSPriority: Oct 5, 2007Filed: Jun 26, 2014Published: Oct 16, 2014
Est. expiryOct 5, 2027(~1.2 yrs left)· nominal 20-yr term from priority
Inventors:Wen ZhangJennifer Riggs-SauthierJ. Milton HarrisMichael D. Bentley
A61P 25/24A61P 25/22A61P 25/00A61P 25/08A61K 31/573C07J 41/0005A61P 1/08A61K 47/60A61K 47/59A61K 47/48215
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Claims

Abstract

The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits different properties compared to the properties of the corticosteroid not attached to the water-soluble oligomer.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A compound comprising a corticosteroid residue covalently attached via a releasable linkage to a poly(ethylene oxide), wherein the corticosteroid residue is a residue dexamethasone and the poly(ethylene oxide) is branched. 
     
     
         2 . The compound of  claim 1 , wherein the molecular weight of the poly(ethylene oxide) is below about 1500 Daltons. 
     
     
         3 . The compound of  claim 1 , wherein the molecular weight of the poly(ethylene oxide) is below about 1300 Daltons. 
     
     
         4 . The compound of  claim 1 , wherein the molecular weight of the poly(ethylene oxide) is below about 1000 Daltons.

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