Methods for Synthesizing Molybdopterin Precursor Z Derivatives

Abstract

Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.

What is claimed is: 
     
         1 . A process for preparing a compound of formula (I): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, the process comprising:
 (a) reacting a compound of formula (II): 
 
       
         
           
           
               
               
           
         
       
       wherein: 
       each R 1  is independently H or a protecting group, 
       with a compound of formula (III): 
       
         
           
           
               
               
           
         
       
       to produce a compound of formula (IV): 
       
         
           
           
               
               
           
         
         (b) selectively protecting the compound of formula (IV) to prepare a compound of formula (V): 
       
       
         
           
           
               
               
           
         
         (c) phosphorylating the compound of formula (V) to prepare a compound of formula (VI): 
       
       
         
           
           
               
               
           
         
         (d) oxidizing the compound of formula (VI) to prepare a compound of formula (VII): 
       
       
         
           
           
               
               
           
         
       
       and
 (e) deprotecting the compound of formula (VII) to prepare the compound of formula (I).