ANTISENSE OLIGONUCLEOTIDES AGAINST cPLA2, COMPOSITIONS AND USES THEREOF

Abstract

Antisense oligonucleotides against cPLA 2 are provided, which are capable of inhibiting cPLA 2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases.

What is claimed is: 
     
         1 . A method of treating a condition related to Aβ plaque accumulation in a subject, comprising administering to the subject a therapeutically effective amount of at least one antisense oligonucleotide comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-6, thereby treating the condition related to Aβ plaque accumulation. 
     
     
         2 . The method of  claim 1 , wherein said condition is selected from the group consisting of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS). 
     
     
         3 . The method of  claim 1 , wherein said condition is Alzheimer's disease or ALS. 
     
     
         4 . The method of  claim 1 , wherein said at least one antisense oligonucleotide consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-6. 
     
     
         5 . The method of  claim 1 , wherein said at least one antisense oligonucleotide comprises an oligonucleotide having a nucleic acid sequence as set forth in SEQ ID NO: 1, an oligonucleotide having a nucleic acid sequence as set forth in SEQ ID NO: 3 and an oligonucleotide having a nucleic acid sequence as set forth in SEQ ID NO: 6. 
     
     
         6 . The method of  claim 3 , wherein said at least one antisense oligonucleotide comprises an oligonucleotide having a nucleic acid sequence as set forth in SEQ ID NO: 1.